Sequence Detail

ID/Version

Q3TSG4 Q80US0 Q8BKB9 Q8BKC1 (UniProt | EBI)

Last sequence update: 2006-05-30
Last annotation update: 2024-07-24

Sequence description from provider

RecName: Full=RNA demethylase ALKBH5 {ECO:0000305}; EC=1.14.11.53 {ECO:0000305|PubMed:29279410, ECO:0000305|PubMed:35939687, ECO:0000305|PubMed:36859428};AltName: Full=Alkylated DNA repair protein alkB homolog 5;AltName: Full=Alpha-ketoglutarate-d

Provider

SWISS-PROT

Sequence

Polypeptide 395 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Alkbh5	alkB homolog 5, RNA demethylase	40	107	3	14

Sequence references in MGI

J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:194218 Zheng G, et al., ALKBH5 is a mammalian RNA demethylase that impacts RNA metabolism and mouse fertility. Mol Cell. 2013 Jan 10;49(1):18-29
J:258382 Tang C, et al., ALKBH5-dependent m6A demethylation controls splicing and stability of long 3'-UTR mRNAs in male germ cells. Proc Natl Acad Sci U S A. 2018 Jan 9;115(2):E325-E333
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:340651 Chen J, et al., Inhibition of ALKBH5 attenuates I/R-induced renal injury in male mice by promoting Ccl28 m6A modification and increasing Treg recruitment. Nat Commun. 2023 Mar 1;14(1):1161
J:340652 Ding C, et al., RNA m(6)A demethylase ALKBH5 regulates the development of gammadelta T cells. Proc Natl Acad Sci U S A. 2022 Aug 16;119(33):e2203318119