Sequence Detail

ID/Version

Q3U1J4 Q3UJC4 Q9QYK0 Q3U8G3 Q9WV39 Q99LV3 Q3U4D0 (UniProt | EBI)

Last sequence update: 2007-03-20
Last annotation update: 2024-11-27

Sequence description from provider

RecName: Full=DNA damage-binding protein 1;AltName: Full=DDB p127 subunit;AltName: Full=Damage-specific DNA-binding protein 1;AltName: Full=UV-damaged DNA-binding factor;

Provider

SWISS-PROT

Sequence

Polypeptide 1140 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Ddb1	damage specific DNA binding protein 1	83	105	3	27

Sequence references in MGI

J:60115 Seki N, et al., cDNA cloning, tissue expression, and chromosomal assignment of a mouse gene, encoding a 127 kDa UV-damaged DNA binding protein which is defective in XPE cells. DNA Res. 1999 Oct 29;6(5):319-22
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:205485 Yu C, et al., CRL4 complex regulates mammalian oocyte survival and reprogramming by activation of TET proteins. Science. 2013 Dec 20;342(6165):1518-21
J:243464 Tong X, et al., CUL4-DDB1-CDT2 E3 Ligase Regulates the Molecular Clock Activity by Promoting Ubiquitination-Dependent Degradation of the Mammalian CRY1. PLoS One. 2015;10(10):e0139725
J:245577 Tong X, et al., DDB1-Mediated CRY1 Degradation Promotes FOXO1-Driven Gluconeogenesis in Liver. Diabetes. 2017 Oct;66(10):2571-2582
J:266543 Zhang YL, et al., DCAF13 promotes pluripotency by negatively regulating SUV39H1 stability during early embryonic development. EMBO J. 2018 Sep 14;37(18)
J:283196 Hirano A, et al., USP7 and TDP-43: Pleiotropic Regulation of Cryptochrome Protein Stability Paces the Oscillation of the Mammalian Circadian Clock. PLoS One. 2016;11(4):e0154263
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:302674 Zhang J, et al., The CRL4-DCAF13 ubiquitin E3 ligase supports oocyte meiotic resumption by targeting PTEN degradation. Cell Mol Life Sci. 2020 Jun;77(11):2181-2197
J:333016 Shan BQ, et al., DCAF13 promotes breast cancer cell proliferation by ubiquitin inhibiting PERP expression. Cancer Sci. 2022 May;113(5):1587-1600