Sequence Detail

ID/Version

Q3U1N2 Q925C2 Q9ESZ4 (UniProt | EBI)

Last sequence update: 2008-02-05
Last annotation update: 2024-07-24

Sequence description from provider

RecName: Full=Sterol regulatory element-binding protein 2 {ECO:0000303|PubMed:29068315}; Short=SREBP-2 {ECO:0000303|PubMed:29068315};AltName: Full=Sterol regulatory element-binding transcription factor 2 {ECO:0000303|PubMed:29068315};Contains: Re

Provider

SWISS-PROT

Sequence

Polypeptide 1130 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Srebf2	sterol regulatory element binding factor 2	56	105	3	40

Sequence references in MGI

J:86518 Horton JD, et al., Activation of cholesterol synthesis in preference to fatty acid synthesis in liver and adipose tissue of transgenic mice overproducing sterol regulatory element-binding protein-2. J Clin Invest. 1998 Jun 1;101(11):2331-9
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:101203 Engelking LJ, et al., Schoenheimer effect explained - feedback regulation of cholesterol synthesis in mice mediated by Insig proteins. J Clin Invest. 2005 Sep;115(9):2489-98
J:115704 Salles J, et al., Acetyl-CoA carboxylase and SREBP expression during peripheral nervous system myelination. Biochim Biophys Acta. 2003 Apr 8;1631(3):229-38
J:172248 Li Y, et al., AMPK phosphorylates and inhibits SREBP activity to attenuate hepatic steatosis and atherosclerosis in diet-induced insulin-resistant mice. Cell Metab. 2011 Apr 6;13(4):376-88
J:249975 Zhang L, et al., Inhibition of cholesterol biosynthesis through RNF145-dependent ubiquitination of SCAP. Elife. 2017 Oct 25;6:e28766
J:289586 Nagoshi E, et al., Nuclear import of sterol regulatory element-binding protein-2, a basic helix-loop-helix-leucine zipper (bHLH-Zip)-containing transcription factor, occurs through the direct interaction of importin beta with HLH-Zip. Mol Biol Cell. 1999 Jul;10(7):2221-33
J:338255 Cheng L, et al., Hepatic mitochondrial NAD + transporter SLC25A47 activates AMPKalpha mediating lipid metabolism and tumorigenesis. Hepatology. 2023 Feb 22;