Sequence Detail

ID/Version

Q3UCV8 Q5M8N1 Q3UY59 Q8R027 (UniProt | EBI)

Last sequence update: 2005-10-11
Last annotation update: 2024-11-27

Sequence description from provider

RecName: Full=Ubiquitin thioesterase otulin {ECO:0000305}; EC=3.4.19.12 {ECO:0000269|PubMed:23708998, ECO:0000269|PubMed:29950720};AltName: Full=Deubiquitinating enzyme otulin {ECO:0000250|UniProtKB:Q96BN8};AltName: Full=OTU domain-containing deub

Provider

SWISS-PROT

Sequence

Polypeptide 352 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Otulin	OTU deubiquitinase with linear linkage specificity	29	103	4	17

Sequence references in MGI

J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:197674 Rivkin E, et al., The linear ubiquitin-specific deubiquitinase gumby regulates angiogenesis. Nature. 2013 Jun 20;498(7454):318-24
J:236075 Damgaard RB, et al., The Deubiquitinase OTULIN Is an Essential Negative Regulator of Inflammation and Autoimmunity. Cell. 2016 Aug 25;166(5):1215-1230.e20
J:264084 Heger K, et al., OTULIN limits cell death and inflammation by deubiquitinating LUBAC. Nature. 2018 Jul;559(7712):120-124