Sequence Detail

ID/Version

Q3UFK8 Q8C7U5 Q9DC30 Q8C7U3 Q9CSY6 Q99KB3 (UniProt | EBI)

Last sequence update: 2007-07-24
Last annotation update: 2024-11-27

Sequence description from provider

RecName: Full=FERM domain-containing protein 8;AltName: Full=iRhom tail-associated protein {ECO:0000303|PubMed:29897333}; Short=iTAP {ECO:0000303|PubMed:29897333};

Provider

SWISS-PROT

Sequence

Polypeptide 466 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Frmd8	FERM domain containing 8	17	98	4	13

Sequence references in MGI

J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:143718 Trost M, et al., The phagosomal proteome in interferon-gamma-activated macrophages. Immunity. 2009 Jan;30(1):143-54
J:264179 Oikonomidi I, et al., iTAP, a novel iRhom interactor, controls TNF secretion by policing the stability of iRhom/TACE. Elife. 2018 Jun 13;7:e35032
J:264397 Kunzel U, et al., FRMD8 promotes inflammatory and growth factor signalling by stabilising the iRhom/ADAM17 sheddase complex. Elife. 2018 Jun 13;7:e35012
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89