Sequence Detail

ID/Version

Q3UHZ5 Q99PM7 (UniProt | EBI)

Last sequence update: 2005-10-11
Last annotation update: 2024-11-27

Sequence description from provider

RecName: Full=Leiomodin-2;AltName: Full=Cardiac leiomodin; Short=C-LMOD;AltName: Full=Leiomodin {ECO:0000305};

Provider

SWISS-PROT

Sequence

Polypeptide 550 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Lmod2	leiomodin 2 (cardiac)	34	103	4	4

Sequence references in MGI

J:69533 Conley CA, et al., Leiomodins: larger members of the tropomodulin (tmod) gene family. Genomics. 2001 Apr 15;73(2):127-39
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:227272 Pappas CT, et al., Knockout of Lmod2 results in shorter thin filaments followed by dilated cardiomyopathy and juvenile lethality. Proc Natl Acad Sci U S A. 2015 Nov 3;112(44):13573-8
J:233669 Li S, et al., Lmod2 piggyBac mutant mice exhibit dilated cardiomyopathy. Cell Biosci. 2016;6:38
J:291010 Ahrens-Nicklas RC, et al., Disruption of cardiac thin filament assembly arising from a mutation in LMOD2: A novel mechanism of neonatal dilated cardiomyopathy. Sci Adv. 2019 Sep;5(9):eaax2066
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:347151 Kuwabara Y, et al., A human FLII gene variant alters sarcomeric actin thin filament length and predisposes to cardiomyopathy. Proc Natl Acad Sci U S A. 2023 May 9;120(19):e2213696120