Sequence Detail

ID/Version

Q3UP24 Q3TAU8 (UniProt | EBI)

Last sequence update: 2005-10-11
Last annotation update: 2024-11-27

Sequence description from provider

RecName: Full=NLR family CARD domain-containing protein 4;AltName: Full=Caspase recruitment domain-containing protein 12;AltName: Full=Ice protease-activating factor; Short=Ipaf;

Provider

SWISS-PROT

Sequence

Polypeptide 1024 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Nlrc4	NLR family, CARD domain containing 4	38	97	2	34

Sequence references in MGI

J:91292 Mariathasan S, et al., Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf. Nature. 2004 Jul 8;430(6996):213-8
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:112670 Miao EA, et al., Cytoplasmic flagellin activates caspase-1 and secretion of interleukin 1beta via Ipaf. Nat Immunol. 2006 Jun;7(6):569-75
J:112671 Franchi L, et al., Cytosolic flagellin requires Ipaf for activation of caspase-1 and interleukin 1beta in salmonella-infected macrophages. Nat Immunol. 2006 Jun;7(6):576-82
J:124378 Lara-Tejero M, et al., Role of the caspase-1 inflammasome in Salmonella typhimurium pathogenesis. J Exp Med. 2006 Jun 12;203(6):1407-12
J:130358 Sutterwala FS, et al., Immune recognition of Pseudomonas aeruginosa mediated by the IPAF/NLRC4 inflammasome. J Exp Med. 2007 Dec 24;204(13):3235-45
J:157567 Miao EA, et al., Innate immune detection of the type III secretion apparatus through the NLRC4 inflammasome. Proc Natl Acad Sci U S A. 2010 Feb 16;107(7):3076-80
J:162695 Akhter A, et al., Caspase-7 activation by the Nlrc4/Ipaf inflammasome restricts Legionella pneumophila infection. PLoS Pathog. 2009 Apr;5(4):e1000361
J:163379 Broz P, et al., Redundant roles for inflammasome receptors NLRP3 and NLRC4 in host defense against Salmonella. J Exp Med. 2010 Aug 2;207(8):1745-55
J:176197 Kofoed EM, et al., Innate immune recognition of bacterial ligands by NAIPs determines inflammasome specificity. Nature. 2011 Sep 29;477(7366):592-5
J:177040 Zhao Y, et al., The NLRC4 inflammasome receptors for bacterial flagellin and type III secretion apparatus. Nature. 2011 Sep 29;477(7366):596-600
J:181212 Kupz A, et al., NLRC4 inflammasomes in dendritic cells regulate noncognate effector function by memory CD8 T cells. Nat Immunol. 2012 Feb;13(2):162-9
J:183161 Tomalka J, et al., A novel role for the NLRC4 inflammasome in mucosal defenses against the fungal pathogen Candida albicans. PLoS Pathog. 2011 Dec;7(12):e1002379
J:185371 Franchi L, et al., NLRC4-driven production of IL-1beta discriminates between pathogenic and commensal bacteria and promotes host intestinal defense. Nat Immunol. 2012 May;13(5):449-56
J:188721 Cai S, et al., NLRC4 inflammasome-mediated production of IL-1beta modulates mucosal immunity in the lung against gram-negative bacterial infection. J Immunol. 2012 Jun 1;188(11):5623-35
J:189256 Qu Y, et al., Phosphorylation of NLRC4 is critical for inflammasome activation. Nature. 2012 Oct 25;490(7421):539-42
J:245242 Zhang L, et al., Cryo-EM structure of the activated NAIP2-NLRC4 inflammasome reveals nucleated polymerization. Science. 2015 Oct 23;350(6259):404-9
J:245334 Hu Z, et al., Crystal structure of NLRC4 reveals its autoinhibition mechanism. Science. 2013 Jul 12;341(6142):172-5
J:247416 Diebolder CA, et al., Cryoelectron Tomography of the NAIP5/NLRC4 Inflammasome: Implications for NLR Activation. Structure. 2015 Dec 01;23(12):2349-57
J:257333 Yang X, et al., Structural basis for specific flagellin recognition by the NLR protein NAIP5. Cell Res. 2018 Jan;28(1):35-47
J:277864 Tenthorey JL, et al., The structural basis of flagellin detection by NAIP5: A strategy to limit pathogen immune evasion. Science. 2017 Nov 17;358(6365):888-893
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:306581 Broz P, et al., Differential requirement for Caspase-1 autoproteolysis in pathogen-induced cell death and cytokine processing. Cell Host Microbe. 2010 Dec 16;8(6):471-83