Sequence Detail

ID/Version

Q3URK3 Q6ZPK2 E9Q9Y4 Q9CY36 D0VLQ4 (UniProt | EBI)

Last sequence update: 2023-05-03
Last annotation update: 2024-11-27

Sequence description from provider

RecName: Full=Methylcytosine dioxygenase TET1; EC=1.14.11.80 {ECO:0000269|PubMed:20639862, ECO:0000269|PubMed:21778364};AltName: Full=CXXC-type zinc finger protein 6;AltName: Full=Ten-eleven translocation 1 gene protein homolog;

Provider

SWISS-PROT

Sequence

Polypeptide 2039 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Tet1	tet methylcytosine dioxygenase 1	45	116	3	225

Sequence references in MGI

J:86686 Okazaki N, et al., Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. DNA Res. 2003 Aug 31;10(4):167-80
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:163464 Ito S, et al., Role of Tet proteins in 5mC to 5hmC conversion, ES-cell self-renewal and inner cell mass specification. Nature. 2010 Jul 18;466(7310):1129-1133
J:171743 Wu H, et al., Dual functions of Tet1 in transcriptional regulation in mouse embryonic stem cells. Nature. 2011 May 19;473(7347):389-93
J:172063 Williams K, et al., TET1 and hydroxymethylcytosine in transcription and DNA methylation fidelity. Nature. 2011 May 19;473(7347):343-8
J:172664 Xu Y, et al., Genome-wide Regulation of 5hmC, 5mC, and Gene Expression by Tet1 Hydroxylase in Mouse Embryonic Stem Cells. Mol Cell. 2011 May 20;42(4):451-64
J:175307 Guo JU, et al., Hydroxylation of 5-methylcytosine by TET1 promotes active DNA demethylation in the adult brain. Cell. 2011 Apr 29;145(3):423-34
J:175793 Ito S, et al., Tet proteins can convert 5-methylcytosine to 5-formylcytosine and 5-carboxylcytosine. Science. 2011 Sep 2;333(6047):1300-3
J:175858 Dawlaty MM, et al., Tet1 is dispensable for maintaining pluripotency and its loss is compatible with embryonic and postnatal development. Cell Stem Cell. 2011 Aug 5;9(2):166-75
J:194056 Dawlaty MM, et al., Combined deficiency of Tet1 and Tet2 causes epigenetic abnormalities but is compatible with postnatal development. Dev Cell. 2013 Feb 11;24(3):310-23
J:194101 Yamaguchi S, et al., Tet1 controls meiosis by regulating meiotic gene expression. Nature. 2012 Dec 20;492(7429):443-7
J:196207 Vella P, et al., Tet proteins connect the O-linked N-acetylglucosamine transferase Ogt to chromatin in embryonic stem cells. Mol Cell. 2013 Feb 21;49(4):645-56
J:205485 Yu C, et al., CRL4 complex regulates mammalian oocyte survival and reprogramming by activation of TET proteins. Science. 2013 Dec 20;342(6165):1518-21
J:219980 Nakagawa T, et al., CRL4(VprBP) E3 ligase promotes monoubiquitylation and chromatin binding of TET dioxygenases. Mol Cell. 2015 Jan 22;57(2):247-60
J:243422 Streubel G, et al., Fam60a defines a variant Sin3a-Hdac complex in embryonic stem cells required for self-renewal. EMBO J. 2017 Aug 01;36(15):2216-2232
J:243754 Khoueiry R, et al., Lineage-specific functions of TET1 in the postimplantation mouse embryo. Nat Genet. 2017 Jul;49(7):1061-1072
J:248790 Zhang W, et al., Isoform Switch of TET1 Regulates DNA Demethylation and Mouse Development. Mol Cell. 2016 Dec 15;64(6):1062-1073
J:253636 Yosefzon Y, et al., An epigenetic switch repressing Tet1 in gonadotropes activates the reproductive axis. Proc Natl Acad Sci U S A. 2017 Sep 19;114(38):10131-10136
J:279902 Burleson JD, et al., TET1 contributes to allergic airway inflammation and regulates interferon and aryl hydrocarbon receptor signaling pathways in bronchial epithelial cells. Sci Rep. 2019 May 14;9(1):7361
J:297016 Damal Villivalam S, et al., TET1 is a beige adipocyte-selective epigenetic suppressor of thermogenesis. Nat Commun. 2020 Aug 27;11(1):4313
J:302141 Greer CB, et al., Tet1 Isoforms Differentially Regulate Gene Expression, Synaptic Transmission, and Memory in the Mammalian Brain. J Neurosci. 2021 Jan 27;41(4):578-593
J:315675 Jiang L, et al., RNF217 regulates iron homeostasis through its E3 ubiquitin ligase activity by modulating ferroportin degradation. Blood. 2021 Aug 26;138(8):689-705
J:320270 Takai H, et al., 5-Hydroxymethylcytosine plays a critical role in glioblastomagenesis by recruiting the CHTOP-methylosome complex. Cell Rep. 2014 Oct 9;9(1):48-60