Sequence Detail

ID/Version

Q3UZP0 Q80UJ4 Q99LE8 (UniProt | EBI)

Last sequence update: 2005-10-11
Last annotation update: 2024-07-24

Sequence description from provider

RecName: Full=MARVEL domain-containing protein 2 {ECO:0000305};AltName: Full=Tricellulin {ECO:0000303|PubMed:21245199, ECO:0000303|PubMed:23239027, ECO:0000303|PubMed:25217574};

Provider

SWISS-PROT

Sequence

Polypeptide 555 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Marveld2	MARVEL (membrane-associating) domain containing 2	33	100	4	7

Sequence references in MGI

J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:104501 Ikenouchi J, et al., Tricellulin constitutes a novel barrier at tricellular contacts of epithelial cells. J Cell Biol. 2005 Dec 19;171(6):939-45
J:122440 Riazuddin S, et al., Tricellulin is a tight-junction protein necessary for hearing. Am J Hum Genet. 2006 Dec;79(6):1040-51
J:200231 Higashi T, et al., Analysis of the 'angulin' proteins LSR, ILDR1 and ILDR2--tricellulin recruitment, epithelial barrier function and implication in deafness pathogenesis. J Cell Sci. 2013 Feb 15;126(Pt 4):966-77
J:217755 Morozko EL, et al., ILDR1 null mice, a model of human deafness DFNB42, show structural aberrations of tricellular tight junctions and degeneration of auditory hair cells. Hum Mol Genet. 2015 Feb 1;24(3):609-24
J:230002 Nakatsu D, et al., JNK1/2-dependent phosphorylation of angulin-1/LSR is required for the exclusive localization of angulin-1/LSR and tricellulin at tricellular contacts in EpH4 epithelial sheet. Genes Cells. 2014 Jul;19(7):565-81
J:261357 Kamitani T, et al., Deletion of Tricellulin Causes Progressive Hearing Loss Associated with Degeneration of Cochlear Hair Cells. Sci Rep. 2015 Dec 18;5:18402
J:276413 Masuda S, et al., LSR defines cell corners for tricellular tight junction formation in epithelial cells. J Cell Sci. 2011 Feb 15;124(Pt 4):548-55
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89