Sequence Detail

ID/Version

Q3ZAS0 (UniProt | EBI)

Last sequence update: 2005-09-27
Last annotation update: 2024-11-27

Sequence description from provider

RecName: Full=Sodium/hydrogen exchanger 2;AltName: Full=Na(+)/H(+) exchanger 2; Short=NHE-2;AltName: Full=Sodium/hydrogen exchanger;AltName: Full=Solute carrier family 9 member 2;

Provider

SWISS-PROT

Sequence

Polypeptide 814 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Slc9a2	solute carrier family 9 (sodium/hydrogen exchanger), member 2	18	102	3	3

Sequence references in MGI

J:46545 Schultheis PJ, et al., Targeted disruption of the murine Na+/H+ exchanger isoform 2 gene causes reduced viability of gastric parietal cells and loss of net acid secretion. J Clin Invest. 1998 Mar 15;101(6):1243-53
J:65754 Boivin GP, et al., Variant form of diffuse corporal gastritis in NHE2 knockout mice. Comp Med. 2000 Oct;50(5):511-5
J:95672 Bachmann O, et al., The Na+/H+ exchanger isoform 2 is the predominant NHE isoform in murine colonic crypts and its lack causes NHE3 upregulation. Am J Physiol Gastrointest Liver Physiol. 2004 Jul;287(1):G125-33
J:108636 Ledoussal C, et al., Loss of the NHE2 Na(+)/H(+) exchanger has no apparent effect on diarrheal state of NHE3-deficient mice. Am J Physiol Gastrointest Liver Physiol. 2001 Dec;281(6):G1385-96
J:116869 Guan Y, et al., NHE2 is the main apical NHE in mouse colonic crypts but an alternative Na+-dependent acid extrusion mechanism is upregulated in NHE2-null mice. Am J Physiol Gastrointest Liver Physiol. 2006 Oct;291(4):G689-99
J:178168 Xue L, et al., Trefoil factor 2 requires na/h exchanger 2 activity to enhance mouse gastric epithelial repair. J Biol Chem. 2011 Nov 4;286(44):38375-82
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:333125 Nikolovska K, et al., Sodium/hydrogen-exchanger-2 modulates colonocyte lineage differentiation. Acta Physiol (Oxf). 2022 Mar;234(3):e13774