Sequence Detail

ID/Version

Q4JK59 Q3U5R5 Q3U633 Q8K2K3 Q6ZPN2 Q3UAI0 (UniProt | EBI)

Last sequence update: 2009-06-16
Last annotation update: 2024-07-24

Sequence description from provider

RecName: Full=Methylcytosine dioxygenase TET2; EC=1.14.11.80 {ECO:0000269|PubMed:20639862, ECO:0000269|PubMed:21057493, ECO:0000269|PubMed:21778364, ECO:0000269|PubMed:21817016};AltName: Full=Protein Ayu17-449;

Provider

SWISS-PROT

Sequence

Polypeptide 1912 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Tet2	tet methylcytosine dioxygenase 2	42	109	3	1073

Sequence references in MGI

J:86686 Okazaki N, et al., Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. DNA Res. 2003 Aug 31;10(4):167-80
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:163464 Ito S, et al., Role of Tet proteins in 5mC to 5hmC conversion, ES-cell self-renewal and inner cell mass specification. Nature. 2010 Jul 18;466(7310):1129-1133
J:168342 Ko M, et al., Impaired hydroxylation of 5-methylcytosine in myeloid cancers with mutant TET2. Nature. 2010 Dec 9;468(7325):839-43
J:174053 Moran-Crusio K, et al., Tet2 loss leads to increased hematopoietic stem cell self-renewal and myeloid transformation. Cancer Cell. 2011 Jul 12;20(1):11-24
J:175793 Ito S, et al., Tet proteins can convert 5-methylcytosine to 5-formylcytosine and 5-carboxylcytosine. Science. 2011 Sep 2;333(6047):1300-3
J:175857 He YF, et al., Tet-mediated formation of 5-carboxylcytosine and its excision by TDG in mammalian DNA. Science. 2011 Sep 2;333(6047):1303-7
J:178415 Li Z, et al., Deletion of Tet2 in mice leads to dysregulated hematopoietic stem cells and subsequent development of myeloid malignancies. Blood. 2011 Oct 27;118(17):4509-18
J:194056 Dawlaty MM, et al., Combined deficiency of Tet1 and Tet2 causes epigenetic abnormalities but is compatible with postnatal development. Dev Cell. 2013 Feb 11;24(3):310-23
J:194101 Yamaguchi S, et al., Tet1 controls meiosis by regulating meiotic gene expression. Nature. 2012 Dec 20;492(7429):443-7
J:194478 Deplus R, et al., TET2 and TET3 regulate GlcNAcylation and H3K4 methylation through OGT and SET1/COMPASS. EMBO J. 2013 Feb 12;32(5):645-55
J:196207 Vella P, et al., Tet proteins connect the O-linked N-acetylglucosamine transferase Ogt to chromatin in embryonic stem cells. Mol Cell. 2013 Feb 21;49(4):645-56
J:205485 Yu C, et al., CRL4 complex regulates mammalian oocyte survival and reprogramming by activation of TET proteins. Science. 2013 Dec 20;342(6165):1518-21
J:219980 Nakagawa T, et al., CRL4(VprBP) E3 ligase promotes monoubiquitylation and chromatin binding of TET dioxygenases. Mol Cell. 2015 Jan 22;57(2):247-60
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:331042 Tang H, et al., Cloning and expression analysis of a murine novel gene, Ayu17-449. Yi Chuan Xue Bao. 2006 May;33(5):413-9