Sequence Detail

ID/Version

Q4U4S6 B2BBR6 Q5S4P7 A2AVA2 Q5S4P8 Q8BS23 A1ECA5 Q5S4P6 (UniProt | EBI)

Last sequence update: 2005-07-05
Last annotation update: 2024-11-27

Sequence description from provider

RecName: Full=Xin actin-binding repeat-containing protein 2 {ECO:0000305};AltName: Full=Beta-xin;AltName: Full=Cardiomyopathy-associated protein 3;AltName: Full=Myogenic MEF2-activated Xin-related protein {ECO:0000303|PubMed:17046827};AltName: Full=Myomax

Provider

SWISS-PROT

Sequence

Polypeptide 3784 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Xirp2	xin actin-binding repeat containing 2	23	105	4	11

Sequence references in MGI

J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:117604 Huang HT, et al., Myomaxin is a novel transcriptional target of MEF2A that encodes a Xin-related alpha-actinin-interacting protein. J Biol Chem. 2006 Dec 22;281(51):39370-9
J:132079 Gustafson-Wagner EA, et al., Loss of mXinalpha, an intercalated disk protein, results in cardiac hypertrophy and cardiomyopathy with conduction defects. Am J Physiol Heart Circ Physiol. 2007 Nov;293(5):H2680-92
J:158491 Wang Q, et al., Essential roles of an intercalated disc protein, mXinbeta, in postnatal heart growth and survival. Circ Res. 2010 May 14;106(9):1468-78
J:228182 Scheffer DI, et al., XIRP2, an actin-binding protein essential for inner ear hair-cell stereocilia. Cell Rep. 2015 Mar 24;10(11):1811-8
J:255706 Huang L, et al., Critical Roles of Xirp Proteins in Cardiac Conduction and Their Rare Variants Identified in Sudden Unexplained Nocturnal Death Syndrome and Brugada Syndrome in Chinese Han Population. J Am Heart Assoc. 2018 Jan 6;7(1)
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:338149 Wagner EL, et al., Repair of noise-induced damage to stereocilia F-actin cores is facilitated by XIRP2 and its novel mechanosensor domain. Elife. 2023 Jun 9;12