Sequence Detail

ID/Version

Q504P2 Q8BN96 (UniProt | EBI)

Last sequence update: 2005-06-07
Last annotation update: 2024-11-27

Sequence description from provider

RecName: Full=C-type lectin domain family 12 member A {ECO:0000305};AltName: Full=Killer cell C-type lectin-like receptor L1 {ECO:0000303|PubMed:15238421}; Short=mKLRL1 {ECO:0000303|PubMed:15238421};AltName: Full=Myeloid inhibitory C-type lectin-l

Provider

SWISS-PROT

Sequence

Polypeptide 267 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Clec12a	C-type lectin domain family 12, member a	22	97	2	11

Sequence references in MGI

J:89520 Marshall AS, et al., Identification and characterization of a novel human myeloid inhibitory C-type lectin-like receptor (MICL) that is predominantly expressed on granulocytes and monocytes. J Biol Chem. 2004 Apr 9;279(15):14792-802
J:94279 Han Y, et al., KLRL1, a novel killer cell lectinlike receptor, inhibits natural killer cell cytotoxicity. Blood. 2004 Nov 1;104(9):2858-66
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:133774 Pyz E, et al., Characterisation of murine MICL (CLEC12A) and evidence for an endogenous ligand. Eur J Immunol. 2008 Apr;38(4):1157-63
J:210326 Neumann K, et al., Clec12a is an inhibitory receptor for uric acid crystals that regulates inflammation in response to cell death. Immunity. 2014 Mar 20;40(3):389-99
J:239788 Redelinghuys P, et al., MICL controls inflammation in rheumatoid arthritis. Ann Rheum Dis. 2016 Jul;75(7):1386-91
J:279357 Li K, et al., The uric acid crystal receptor Clec12A potentiates type I interferon responses. Proc Natl Acad Sci U S A. 2019 Sep 10;116(37):18544-18549
J:284431 Raulf MK, et al., The C-type Lectin Receptor CLEC12A Recognizes Plasmodial Hemozoin and Contributes to Cerebral Malaria Development. Cell Rep. 2019 Jul 2;28(1):30-38.e5
J:333841 Nishimura N, et al., Mycobacterial mycolic acids trigger inhibitory receptor Clec12A to suppress host immune responses. Tuberculosis (Edinb). 2023 Jan;138:102294
J:355631 Vitry J, et al., Regulation of the Expression, Oligomerisation and Signaling of the Inhibitory Receptor CLEC12A by Cysteine Residues in the Stalk Region. Int J Mol Sci. 2021 Sep 22;22(19)
J:355680 Malamud M, et al., Recognition and control of neutrophil extracellular trap formation by MICL. Nature. 2024 Sep;633(8029):442-450
J:357967 Liu G, et al., mKLRL1 regulates the maturation of dendritic cells and plays important roles in immune tolerance. Am J Transl Res. 2019;11(1):300-313