Sequence Detail

ID/Version

Q5BKR2 Q8CDX4 Q8CA47 (UniProt | EBI)

Last sequence update: 2011-07-27
Last annotation update: 2024-07-24

Sequence description from provider

RecName: Full=Sodium/hydrogen exchanger 9B2;AltName: Full=NHA-oc {ECO:0000303|PubMed:17988971};AltName: Full=Na(+)/H(+) exchanger NHA2;AltName: Full=Na(+)/H(+) exchanger-like domain-containing protein 2; Short=NHE domain-containing protein 2;AltNa

Provider

SWISS-PROT

Sequence

Polypeptide 547 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Slc9b2	solute carrier family 9, subfamily B (NHA2, cation proton antiporter 2), member 2	31	98	3	43

Sequence references in MGI

J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:134223 Lee SH, et al., NHE10, a novel osteoclast-specific member of the Na+/H+ exchanger family, regulates osteoclast differentiation and survival. Biochem Biophys Res Commun. 2008 May 2;369(2):320-6
J:162142 Hofstetter W, et al., Sodium/hydrogen exchanger NHA2 in osteoclasts: subcellular localization and role in vitro and in vivo. Bone. 2010 Aug;47(2):331-40
J:193573 Charles JF, et al., The collection of NFATc1-dependent transcripts in the osteoclast includes numerous genes non-essential to physiologic bone resorption. Bone. 2012 Nov;51(5):902-12
J:197386 Deisl C, et al., Sodium/hydrogen exchanger NHA2 is critical for insulin secretion in beta-cells. Proc Natl Acad Sci U S A. 2013 Jun 11;110(24):10004-9
J:240371 Chen SR, et al., Sodium-hydrogen exchanger NHA1 and NHA2 control sperm motility and male fertility. Cell Death Dis. 2016 Mar 24;7:e2152
J:333977 Kondapalli KC, et al., NHA2 is expressed in distal nephron and regulated by dietary sodium. J Physiol Biochem. 2017 May;73(2):199-205
J:334240 Anderegg MA, et al., The sodium/proton exchanger NHA2 regulates blood pressure through a WNK4-NCC dependent pathway in the kidney. Kidney Int. 2021 Feb;99(2):350-363