Sequence Detail

ID/Version

Q5QNS5 Q8VIM1 Q7TPU2 Q8VIM2 (UniProt | EBI)

Last sequence update: 2005-08-30
Last annotation update: 2024-07-24

Sequence description from provider

RecName: Full=Hepatitis A virus cellular receptor 1 homolog; Short=HAVcr-1;AltName: Full=Kidney injury molecule 1; Short=KIM-1;AltName: Full=T cell immunoglobulin and mucin domain-containing protein 1; Short=TIMD-1;AltName: Full=T

Provider

SWISS-PROT

Sequence

Polypeptide 305 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Havcr1	hepatitis A virus cellular receptor 1	21	98	3	12

Sequence references in MGI

J:72894 McIntire JJ, et al., Identification of Tapr (an airway hyperreactivity regulatory locus) and the linked Tim gene family. Nat Immunol. 2001 Dec;2(12):1109-16
J:120143 Santiago C, et al., Structures of T Cell immunoglobulin mucin receptors 1 and 2 reveal mechanisms for regulation of immune responses by the TIM receptor family. Immunity. 2007 Mar;26(3):299-310
J:178259 Ding Q, et al., Regulatory B cells are identified by expression of TIM-1 and can be induced through TIM-1 ligation to promote tolerance in mice. J Clin Invest. 2011 Sep 1;121(9):3645-56
J:209961 Angiari S, et al., TIM-1 glycoprotein binds the adhesion receptor P-selectin and mediates T cell trafficking during inflammation and autoimmunity. Immunity. 2014 Apr 17;40(4):542-53
J:261838 Meyers JH, et al., TIM-4 is the ligand for TIM-1, and the TIM-1-TIM-4 interaction regulates T cell proliferation. Nat Immunol. 2005 May;6(5):455-64
J:301616 Xiao S, et al., Checkpoint Receptor TIGIT Expressed on Tim-1(+) B Cells Regulates Tissue Inflammation. Cell Rep. 2020 Jul 14;32(2):107892
J:302611 Xiao S, et al., Tim-1 is essential for induction and maintenance of IL-10 in regulatory B cells and their regulation of tissue inflammation. J Immunol. 2015 Feb 15;194(4):1602-8
J:312758 Yeung MY, et al., TIM-1 signaling is required for maintenance and induction of regulatory B cells. Am J Transplant. 2015 Apr;15(4):942-53