Sequence Detail

ID/Version

Q5SSZ7 B2RXA5 Q3V095 (UniProt | EBI)

Last sequence update: 2004-12-21
Last annotation update: 2024-11-27

Sequence description from provider

RecName: Full=E3 ubiquitin-protein ligase ZNRF3; EC=2.3.2.27;AltName: Full=RING-type E3 ubiquitin transferase ZNRF3;AltName: Full=Zinc/RING finger protein 3;Flags: Precursor;

Provider

SWISS-PROT

Sequence

Polypeptide 913 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Znrf3	zinc and ring finger 3	32	100	3	24

Sequence references in MGI

J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:184507 Hao HX, et al., ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner. Nature. 2012 May 10;485(7397):195-200
J:186765 Koo BK, et al., Tumour suppressor RNF43 is a stem-cell E3 ligase that induces endocytosis of Wnt receptors. Nature. 2012 Aug 30;488(7413):665-9
J:262420 Szenker-Ravi E, et al., RSPO2 inhibition of RNF43 and ZNRF3 governs limb development independently of LGR4/5/6. Nature. 2018 May;557(7706):564-569
J:274568 Choi JH, et al., LMBR1L regulates lymphopoiesis through Wnt/beta-catenin signaling. Science. 2019 May 10;364(6440)