Sequence Detail

ID/Version

Q60631 Q61240 (UniProt | EBI)

Last sequence update: 1996-11-01
Last annotation update: 2024-07-24

Sequence description from provider

RecName: Full=Growth factor receptor-bound protein 2;AltName: Full=Adapter protein GRB2;AltName: Full=SH2/SH3 adapter GRB2;

Provider

SWISS-PROT

Sequence

Polypeptide 217 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Grb2	growth factor receptor bound protein 2	140	104	4	53

Sequence references in MGI

J:14183 Suen KL, et al., Molecular cloning of the mouse grb2 gene: differential interaction of the Grb2 adaptor protein with epidermal growth factor and nerve growth factor receptors. Mol Cell Biol. 1993 Sep;13(9):5500-12
J:44628 Yamaguchi A, et al., An Eps homology (EH) domain protein that binds to the Ral-GTPase target, RalBP1. J Biol Chem. 1997 Dec 12;272(50):31230-4
J:53418 Nishida K, et al., Gab-family adapter proteins act downstream of cytokine and growth factor receptors and T- and B-cell antigen receptors. Blood. 1999 Mar 15;93(6):1809-16
J:55014 Goyal RK, et al., Ajuba, a novel LIM protein, interacts with Grb2, augments mitogen- activated protein kinase activity in fibroblasts, and promotes meiotic maturation of Xenopus oocytes in a Grb2- and Ras-dependent manner. Mol Cell Biol. 1999 Jun;19(6):4379-89
J:72874 Spielhaupter C, et al., PrPC Directly Interacts with Proteins Involved in Signaling Pathways. J Biol Chem. 2001 Nov 30;276(48):44604-12
J:73962 Seykora JT, et al., 'Srcasm: a novel Src activating and signaling molecule. J Biol Chem. 2002 Jan 25;277(4):2812-22
J:93950 Volna P, et al., Negative regulation of mast cell signaling and function by the adaptor LAB/NTAL. J Exp Med. 2004 Oct 18;200(8):1001-13
J:93951 Zhu M, et al., Positive and negative regulation of FcepsilonRI-mediated signaling by the adaptor protein LAB/NTAL. J Exp Med. 2004 Oct 18;200(8):991-1000
J:129312 Ahn E, et al., LIME acts as a transmembrane adapter mediating BCR-dependent B-cell activation. Blood. 2006 Feb 15;107(4):1521-7
J:151075 Lesourne R, et al., Themis, a T cell-specific protein important for late thymocyte development. Nat Immunol. 2009 Aug;10(8):840-7
J:151076 Johnson AL, et al., Themis is a member of a new metazoan gene family and is required for the completion of thymocyte positive selection. Nat Immunol. 2009 Aug;10(8):831-9
J:153235 Patrick MS, et al., Gasp, a Grb2-associating protein, is critical for positive selection of thymocytes. Proc Natl Acad Sci U S A. 2009 Sep 22;106(38):16345-50
J:169648 Murata Y, et al., Tyrosine phosphorylation of R3 subtype receptor-type protein tyrosine phosphatases and their complex formations with Grb2 or Fyn. Genes Cells. 2010 May;15(5):513-24
J:177164 Vindis C, et al., EphB1 recruits c-Src and p52Shc to activate MAPK/ERK and promote chemotaxis. J Cell Biol. 2003 Aug 18;162(4):661-71
J:178776 Draber P, et al., SCIMP, a transmembrane adaptor protein involved in major histocompatibility complex class II signaling. Mol Cell Biol. 2011 Nov;31(22):4550-62
J:186446 Wang D, et al., Tespa1 is involved in late thymocyte development through the regulation of TCR-mediated signaling. Nat Immunol. 2012 Jun;13(6):560-8
J:190009 Xu XX, et al., Disabled-2 (Dab2) is an SH3 domain-binding partner of Grb2. Oncogene. 1998 Mar 26;16(12):1561-9
J:200496 Wu C, et al., Rab13-dependent trafficking of RhoA is required for directional migration and angiogenesis. J Biol Chem. 2011 Jul 1;286(26):23511-20
J:200516 Jones N, et al., Identification of Tek/Tie2 binding partners. Binding to a multifunctional docking site mediates cell survival and migration. J Biol Chem. 1999 Oct 22;274(43):30896-905
J:213907 Oak SA, et al., Mouse alpha1-syntrophin binding to Grb2: further evidence of a role for syntrophin in cell signaling. Biochemistry. 2001 Sep 18;40(37):11270-8
J:244275 Luo L, et al., SCIMP is a transmembrane non-TIR TLR adaptor that promotes proinflammatory cytokine production from macrophages. Nat Commun. 2017 Jan 18;8:14133
J:276512 Luo L, et al., Development of SH2 probes and pull-down assays to detect pathogen-induced, site-specific tyrosine phosphorylation of the TLR adaptor SCIMP. Immunol Cell Biol. 2017 Jul;95(6):564-570
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:296018 Kumar A, et al., SWELL1 regulates skeletal muscle cell size, intracellular signalling, adiposity and glucose metabolism. Elife. 2020 Sep 15;9:e58941