Sequence Detail

ID/Version

Q60700 P70286 Q3TLL7 Q8C4N7 Q8CBX3 Q8CDL6 (UniProt | EBI)

Last sequence update: 1996-11-01
Last annotation update: 2024-11-27

Sequence description from provider

RecName: Full=Mitogen-activated protein kinase kinase kinase 12; EC=2.7.11.25 {ECO:0000269|PubMed:7983011, ECO:0000269|PubMed:8663324};AltName: Full=Dual leucine zipper bearing kinase; Short=DLK;AltName: Full=Leucine-zipper protein kinase;

Provider

SWISS-PROT

Sequence

Polypeptide 888 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Map3k12	mitogen-activated protein kinase kinase kinase 12	30	111	3	31

Sequence references in MGI

J:20630 Holzman LB, et al., Identification, molecular cloning, and characterization of dual leucine zipper bearing kinase. A novel serine/threonine protein kinase that defines a second subfamily of mixed lineage kinases. J Biol Chem. 1994 Dec 9;269(49):30808-17
J:35108 Blouin R, et al., Cell-specific expression of the ZPK gene in adult mouse tissues. DNA Cell Biol. 1996 Aug;15(8):631-42
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:113678 Mata M, et al., Characterization of dual leucine zipper-bearing kinase, a mixed lineage kinase present in synaptic terminals whose phosphorylation state is regulated by membrane depolarization via calcineurin. J Biol Chem. 1996 Jul 12;271(28):16888-96
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89