Sequence Detail

ID/Version

Q60707 Q5SSP7 (UniProt | EBI)

Last sequence update: 2011-07-27
Last annotation update: 2024-11-27

Sequence description from provider

RecName: Full=T-box transcription factor TBX2; Short=T-box protein 2;

Provider

SWISS-PROT

Sequence

Polypeptide 711 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Tbx2	T-box 2	87	154	4	19

Sequence references in MGI

J:18978 Bollag RJ, et al., An ancient family of embryonically expressed mouse genes sharing a conserved protein motif with the T locus. Nat Genet. 1994 Jul;7(3):383-9
J:34541 Chapman DL, et al., Expression of the T-box family genes, Tbx1-Tbx5, during early mouse development. Dev Dyn. 1996 Aug;206(4):379-90
J:63660 Carreira S, et al., The gene encoding the T-box factor Tbx2 is a target for the microphthalmia-associated transcription factor in melanocytes. J Biol Chem. 2000 Jul 21;275(29):21920-7
J:75292 Paxton C, et al., Murine Tbx2 contains domains that activate and repress gene transcription. Gene. 2002 Jan 23;283(1-2):117-24
J:76656 Habets PE, et al., Cooperative action of Tbx2 and Nkx2.5 inhibits ANF expression in the atrioventricular canal: implications for cardiac chamber formation. Genes Dev. 2002 May 15;16(10):1234-46
J:93610 Harrelson Z, et al., Tbx2 is essential for patterning the atrioventricular canal and for morphogenesis of the outflow tract during heart development. Development. 2004 Oct;131(20):5041-52
J:102855 Jerome-Majewska LA, et al., Tbx3, the ulnar-mammary syndrome gene, and Tbx2 interact in mammary gland development through a p19Arf/p53-independent pathway. Dev Dyn. 2005 Dec;234(4):922-33
J:178974 Sakabe M, et al., Ectopic retinoic acid signaling affects outflow tract cushion development through suppression of the myocardial Tbx2-Tgfbeta2 pathway. Development. 2012 Jan;139(2):385-95
J:236373 Ludtke TH, et al., Tbx2 and Tbx3 Act Downstream of Shh to Maintain Canonical Wnt Signaling during Branching Morphogenesis of the Murine Lung. Dev Cell. 2016 Oct 24;39(2):239-253
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:305429 Kaiser M, et al., Regulation of otocyst patterning by Tbx2 and Tbx3 is required for inner ear morphogenesis in the mouse. Development. 2021 Apr 15;148(8):dev195651
J:313947 Abrahams A, et al., UV-mediated regulation of the anti-senescence factor Tbx2. J Biol Chem. 2008 Jan 25;283(4):2223-30
J:313949 Pan L, et al., Microphthalmia-associated transcription factor/T-box factor-2 axis acts through Cyclin D1 to regulate melanocyte proliferation. Cell Prolif. 2015 Dec;48(6):631-42
J:314218 Wang J, et al., The T-Box Transcription Factor TBX2 Regulates Cell Proliferation in the Retinal Pigment Epithelium. Curr Eye Res. 2017 Nov;42(11):1537-1544
J:314219 Chen Y, et al., The transcription factor TBX2 regulates melanogenesis in melanocytes by repressing Oca2. Mol Cell Biochem. 2016 Apr;415(1-2):103-9
J:314845 Carreira S, et al., Brachyury-related transcription factor Tbx2 and repression of the melanocyte-specific TRP-1 promoter. Mol Cell Biol. 1998 Sep;18(9):5099-108