Sequence Detail

ID/Version

Q60710 Q91VK8 Q543A4 F8WJE0 E9Q0K6 Q3U5X2 (UniProt | EBI)

Last sequence update: 2018-07-18
Last annotation update: 2024-07-24

Sequence description from provider

RecName: Full=Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 {ECO:0000305}; Short=dNTPase {ECO:0000305}; EC=3.1.5.- {ECO:0000269|PubMed:29379009, ECO:0000269|PubMed:31548683};AltName: Full=Interferon-gamma-inducible protein Mg11 {

Provider

SWISS-PROT

Sequence

Polypeptide 658 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Samhd1	SAM domain and HD domain, 1	58	97	4	16

Sequence references in MGI

J:23604 Lafuse WP, et al., Cloning and characterization of a novel cDNA that is IFN-gamma-induced in mouse peritoneal macrophages and encodes a putative GTP-binding protein. J Leukoc Biol. 1995 Mar;57(3):477-83
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:201909 Rehwinkel J, et al., SAMHD1-dependent retroviral control and escape in mice. EMBO J. 2013 Sep 11;32(18):2454-62
J:202757 Behrendt R, et al., Mouse SAMHD1 has antiretroviral activity and suppresses a spontaneous cell-intrinsic antiviral response. Cell Rep. 2013 Aug 29;4(4):689-96
J:258241 Buzovetsky O, et al., The SAM domain of mouse SAMHD1 is critical for its activation and regulation. Nat Commun. 2018 Jan 29;9(1):411
J:262069 Thientosapol ES, et al., SAMHD1 enhances immunoglobulin hypermutation by promoting transversion mutation. Proc Natl Acad Sci U S A. 2018 May 8;115(19):4921-4926
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:293521 Deutschmann J, et al., A viral kinase counteracts in vivo restriction of murine cytomegalovirus by SAMHD1. Nat Microbiol. 2019 Dec;4(12):2273-2284