Sequence Detail

ID/Version

Q60779 Q99L71 (UniProt | EBI)

Last sequence update: 2003-07-19
Last annotation update: 2024-07-24

Sequence description from provider

RecName: Full=Dynein regulatory complex subunit 4 {ECO:0000303|PubMed:27472056};AltName: Full=Growth arrest-specific protein 11; Short=GAS-11;AltName: Full=Growth arrest-specific protein 8; Short=GAS-8;

Provider

SWISS-PROT

Sequence

Polypeptide 478 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Gas8	growth arrest specific 8	44	98	3	4

Sequence references in MGI

J:74672 Yeh SD, et al., Isolation and properties of Gas8, a growth arrest-specific gene regulated during male gametogenesis to produce a protein associated with the sperm motility apparatus. J Biol Chem. 2002 Feb 22;277(8):6311-7
J:136617 Nishimura N, et al., Interaction of Rab3B with microtubule-binding protein Gas8 in NIH 3T3 cells. Arch Biochem Biophys. 2008 Jun 1;474(1):136-42
J:230755 Olbrich H, et al., Loss-of-Function GAS8 Mutations Cause Primary Ciliary Dyskinesia and Disrupt the Nexin-Dynein Regulatory Complex. Am J Hum Genet. 2015 Oct 1;97(4):546-54
J:233581 Bekker JM, et al., Direct interaction of Gas11 with microtubules: implications for the dynein regulatory complex. Cell Motil Cytoskeleton. 2007 Jun;64(6):461-73
J:233582 Colantonio JR, et al., Expanding the role of the dynein regulatory complex to non-axonemal functions: association of GAS11 with the Golgi apparatus. Traffic. 2006 May;7(5):538-48
J:234173 Lewis WR, et al., Mutation of Growth Arrest Specific 8 Reveals a Role in Motile Cilia Function and Human Disease. PLoS Genet. 2016 Jul;12(7):e1006220
J:259132 Evron T, et al., Growth Arrest Specific 8 (Gas8) and G protein-coupled receptor kinase 2 (GRK2) cooperate in the control of Smoothened signaling. J Biol Chem. 2011 Aug 5;286(31):27676-86
J:284740 Morohoshi A, et al., Nexin-Dynein regulatory complex component DRC7 but not FBXL13 is required for sperm flagellum formation and male fertility in mice. PLoS Genet. 2020 Jan;16(1):e1008585