Sequence Detail

ID/Version

Q60823 (UniProt | EBI)

Last sequence update: 1996-11-01
Last annotation update: 2024-07-24

Sequence description from provider

RecName: Full=RAC-beta serine/threonine-protein kinase; EC=2.7.11.1;AltName: Full=Protein kinase Akt-2;AltName: Full=Protein kinase B beta; Short=PKB beta;AltName: Full=RAC-PK-beta;

Provider

SWISS-PROT

Sequence

Polypeptide 481 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Akt2	thymoma viral proto-oncogene 2	102	112	4	53

Sequence references in MGI

J:29076 Altomare DA, et al., Cloning, chromosomal localization and expression analysis of the mouse Akt2 oncogene. Oncogene. 1995 Sep 21;11(6):1055-60
J:145864 Ding J, et al., ClipR-59 interacts with Akt and regulates Akt cellular compartmentalization. Mol Cell Biol. 2009 Mar;29(6):1459-71
J:157003 Rodgers JT, et al., Cdc2-like kinase 2 is an insulin-regulated suppressor of hepatic gluconeogenesis. Cell Metab. 2010 Jan;11(1):23-34
J:176652 Xie X, et al., C2 Domain-Containing Phosphoprotein CDP138 Regulates GLUT4 Insertion into the Plasma Membrane. Cell Metab. 2011 Sep 7;14(3):378-89
J:183035 Cenni V, et al., Ankrd2/ARPP is a novel Akt2 specific substrate and regulates myogenic differentiation upon cellular exposure to H(2)O(2). Mol Biol Cell. 2011 Aug 15;22(16):2946-56
J:186376 Gherzi R, et al., Akt2-mediated phosphorylation of Pitx2 controls Ccnd1 mRNA decay during muscle cell differentiation. Cell Death Differ. 2010 Jun;17(6):975-83
J:213891 Nawa M, et al., KCTD20, a relative of BTBD10, is a positive regulator of Akt. BMC Biochem. 2013;14:27
J:213903 Nawa M, et al., A novel Akt/PKB-interacting protein promotes cell adhesion and inhibits familial amyotrophic lateral sclerosis-linked mutant SOD1-induced neuronal death via inhibition of PP2A-mediated dephosphorylation of Akt/PKB. Cell Signal. 2008 Mar;20(3):493-505
J:225409 Fritzius T, et al., A WD-FYVE protein binds to the kinases Akt and PKCzeta/lambda. Biochem J. 2006 Oct 1;399(1):9-20
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89