Sequence Detail

ID/Version

Q60838 Q7TN14 (UniProt | EBI)

Last sequence update: 2011-07-27
Last annotation update: 2024-07-24

Sequence description from provider

RecName: Full=Segment polarity protein dishevelled homolog DVL-2; Short=Dishevelled-2;AltName: Full=DSH homolog 2;

Provider

SWISS-PROT

Sequence

Polypeptide 736 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Dvl2	dishevelled segment polarity protein 2	90	130	2	21

Sequence references in MGI

J:35543 Klingensmith J, et al., Conservation of dishevelled structure and function between flies and mice: isolation and characterization of Dvl2. Mech Dev. 1996 Aug;58(1-2):15-26
J:95171 Torban E, et al., Independent mutations in mouse Vangl2 that cause neural tube defects in looptail mice impair interaction with members of the Dishevelled family. J Biol Chem. 2004 Dec 10;279(50):52703-13
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:175318 Liu YT, et al., Molecular basis of Wnt activation via the DIX domain protein Ccd1. J Biol Chem. 2011 Mar 11;286(10):8597-608
J:197674 Rivkin E, et al., The linear ubiquitin-specific deubiquitinase gumby regulates angiogenesis. Nature. 2013 Jun 20;498(7454):318-24
J:221860 Miyatake K, et al., ERK7 regulates ciliogenesis by phosphorylating the actin regulator CapZIP in cooperation with Dishevelled. Nat Commun. 2015;6:6666
J:236814 Kim S, et al., The polycystin complex mediates Wnt/Ca(2+) signalling. Nat Cell Biol. 2016 Jul;18(7):752-64
J:245339 Yu A, et al., Structural analysis of the interaction between Dishevelled2 and clathrin AP-2 adaptor, a critical step in noncanonical Wnt signaling. Structure. 2010 Oct 13;18(10):1311-20
J:274568 Choi JH, et al., LMBR1L regulates lymphopoiesis through Wnt/beta-catenin signaling. Science. 2019 May 10;364(6440)
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89