Sequence Detail

ID/Version

Q60867 Q545N9 Q60897 (UniProt | EBI)

Last sequence update: 1997-02-01
Last annotation update: 2024-05-29

Sequence description from provider

RecName: Full=Neurogenic differentiation factor 1; Short=NeuroD1;AltName: Full=Beta-cell E-box transcriptional activator 2; Short=Beta2;

Provider

SWISS-PROT

Sequence

Polypeptide 357 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Neurod1	neurogenic differentiation 1	83	220	3	14

Sequence references in MGI

J:25296 Lee JE, et al., Conversion of Xenopus ectoderm into neurons by NeuroD, a basic helix-loop-helix protein. Science. 1995 May 12;268(5212):836-44
J:43010 Naya FJ, et al., Diabetes, defective pancreatic morphogenesis, and abnormal enteroendocrine differentiation in BETA2/neuroD-deficient mice. Genes Dev. 1997 Sep 15;11(18):2323-34
J:59932 Liu M, et al., Loss of BETA2/NeuroD leads to malformation of the dentate gyrus and epilepsy [published erratum appears in Proc Natl Acad Sci U S A 2000 May 9;97(10):5679]. Proc Natl Acad Sci U S A. 2000 Jan 18;97(2):865-70
J:66787 Kim WY, et al., NeuroD-null mice are deaf due to a severe loss of the inner ear sensory neurons during development. Development. 2001 Feb;128(3):417-26
J:74573 Inoue T, et al., Math3 and NeuroD regulate amacrine cell fate specification in the retina. Development. 2002 Feb;129(4):831-42
J:74715 Miyata T, et al., NeuroD is required for differentiation of the granule cells in the cerebellum and hippocampus. Genes Dev. 1999 Jul 1;13(13):1647-52
J:87366 Lin CH, et al., Regulation of neuroD2 expression in mouse brain. Dev Biol. 2004 Jan 1;265(1):234-45
J:89077 Kim JY, et al., Orphan nuclear receptor small heterodimer partner, a novel corepressor for a basic helix-loop-helix transcription factor BETA2/neuroD. Mol Endocrinol. 2004 Apr;18(4):776-90
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:137207 Lynn FC, et al., Identification of the bHLH factor Math6 as a novel component of the embryonic pancreas transcriptional network. PLoS One. 2008;3(6):e2430
J:137934 Neptune ER, et al., Targeted disruption of NeuroD, a proneural basic helix-loop-helix factor, impairs distal lung formation and neuroendocrine morphology in the neonatal lung. J Biol Chem. 2008 Jul 25;283(30):21160-9
J:156329 Anderson KR, et al., Cooperative transcriptional regulation of the essential pancreatic islet gene NeuroD1 (beta2) by Nkx2.2 and neurogenin 3. J Biol Chem. 2009 Nov 6;284(45):31236-48
J:172919 Mutoh H, et al., The basic helix-loop-helix protein BETA2 interacts with p300 to coordinate differentiation of secretin-expressing enteroendocrine cells. Genes Dev. 1998 Mar 15;12(6):820-30
J:172976 Seo S, et al., Neurogenin and NeuroD direct transcriptional targets and their regulatory enhancers. EMBO J. 2007 Dec 12;26(24):5093-108
J:173356 Cherry TJ, et al., NeuroD factors regulate cell fate and neurite stratification in the developing retina. J Neurosci. 2011 May 18;31(20):7365-79
J:302456 Davies OR, et al., Tcf15 primes pluripotent cells for differentiation. Cell Rep. 2013 Feb 21;3(2):472-84