ID/Version |
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Sequence description from provider |
RecName: Full=Neurogenic differentiation factor 1; Short=NeuroD1;AltName: Full=Beta-cell E-box transcriptional activator 2; Short=Beta2; | ||||||||||||||
Provider | SWISS-PROT | ||||||||||||||
Sequence |
Polypeptide
357
aa
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Annotated genes and markers |
Follow the symbol links to get more information on the GO terms,
expression assays, orthologs, phenotypic alleles, and other information
for the genes or markers below.
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Sequence references in MGI |
J:25296
Lee JE, et al., Conversion of Xenopus ectoderm into neurons by NeuroD, a basic helix-loop-helix protein. Science. 1995 May 12;268(5212):836-44
J:43010 Naya FJ, et al., Diabetes, defective pancreatic morphogenesis, and abnormal enteroendocrine differentiation in BETA2/neuroD-deficient mice. Genes Dev. 1997 Sep 15;11(18):2323-34 J:59932 Liu M, et al., Loss of BETA2/NeuroD leads to malformation of the dentate gyrus and epilepsy [published erratum appears in Proc Natl Acad Sci U S A 2000 May 9;97(10):5679]. Proc Natl Acad Sci U S A. 2000 Jan 18;97(2):865-70 J:66787 Kim WY, et al., NeuroD-null mice are deaf due to a severe loss of the inner ear sensory neurons during development. Development. 2001 Feb;128(3):417-26 J:74573 Inoue T, et al., Math3 and NeuroD regulate amacrine cell fate specification in the retina. Development. 2002 Feb;129(4):831-42 J:74715 Miyata T, et al., NeuroD is required for differentiation of the granule cells in the cerebellum and hippocampus. Genes Dev. 1999 Jul 1;13(13):1647-52 J:87366 Lin CH, et al., Regulation of neuroD2 expression in mouse brain. Dev Biol. 2004 Jan 1;265(1):234-45 J:89077 Kim JY, et al., Orphan nuclear receptor small heterodimer partner, a novel corepressor for a basic helix-loop-helix transcription factor BETA2/neuroD. Mol Endocrinol. 2004 Apr;18(4):776-90 J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563 J:137207 Lynn FC, et al., Identification of the bHLH factor Math6 as a novel component of the embryonic pancreas transcriptional network. PLoS One. 2008;3(6):e2430 J:137934 Neptune ER, et al., Targeted disruption of NeuroD, a proneural basic helix-loop-helix factor, impairs distal lung formation and neuroendocrine morphology in the neonatal lung. J Biol Chem. 2008 Jul 25;283(30):21160-9 J:156329 Anderson KR, et al., Cooperative transcriptional regulation of the essential pancreatic islet gene NeuroD1 (beta2) by Nkx2.2 and neurogenin 3. J Biol Chem. 2009 Nov 6;284(45):31236-48 J:172919 Mutoh H, et al., The basic helix-loop-helix protein BETA2 interacts with p300 to coordinate differentiation of secretin-expressing enteroendocrine cells. Genes Dev. 1998 Mar 15;12(6):820-30 J:172976 Seo S, et al., Neurogenin and NeuroD direct transcriptional targets and their regulatory enhancers. EMBO J. 2007 Dec 12;26(24):5093-108 J:173356 Cherry TJ, et al., NeuroD factors regulate cell fate and neurite stratification in the developing retina. J Neurosci. 2011 May 18;31(20):7365-79 J:302456 Davies OR, et al., Tcf15 primes pluripotent cells for differentiation. Cell Rep. 2013 Feb 21;3(2):472-84 |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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