Sequence Detail

ID/Version

Q60932 B1ASZ9 Q5SVC6 (UniProt | EBI)

Last sequence update: 2000-12-01
Last annotation update: 2024-07-24

Sequence description from provider

RecName: Full=Non-selective voltage-gated ion channel VDAC1 {ECO:0000305};AltName: Full=Outer mitochondrial membrane protein porin 1;AltName: Full=Plasmalemmal porin;AltName: Full=Voltage-dependent anion-selective channel protein 1; Short=VDAC-1;

Provider

SWISS-PROT

Sequence

Polypeptide 296 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Vdac1	voltage-dependent anion channel 1	75	116	3	120

Sequence references in MGI

J:32840 Sampson MJ, et al., Isolation, characterization, and mapping of two mouse mitochondrial voltage-dependent anion channel isoforms. Genomics. 1996 Apr 15;33(2):283-8
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:150318 Ujwal R, et al., The crystal structure of mouse VDAC1 at 2.3 A resolution reveals mechanistic insights into metabolite gating. Proc Natl Acad Sci U S A. 2008 Nov 18;105(46):17742-7
J:196142 Rardin MJ, et al., Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways. Proc Natl Acad Sci U S A. 2013 Apr 16;110(16):6601-6
J:203468 Park J, et al., SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways. Mol Cell. 2013 Jun 27;50(6):919-30
J:215903 Fernandez-Echevarria C, et al., Abeta promotes VDAC1 channel dephosphorylation in neuronal lipid rafts. Relevance to the mechanisms of neurotoxicity in Alzheimer's disease. Neuroscience. 2014 Oct 10;278:354-66
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:320008 Ham SJ, et al., Decision between mitophagy and apoptosis by Parkin via VDAC1 ubiquitination. Proc Natl Acad Sci U S A. 2020 Feb 25;117(8):4281-4291
J:343398 Cheng YS, et al., A proteome-wide map of 20(S)-hydroxycholesterol interactors in cell membranes. Nat Chem Biol. 2021 Dec;17(12):1271-1280