Sequence Detail

ID/Version

Q60943 (UniProt | EBI)

Last sequence update: 1996-11-01
Last annotation update: 2024-07-24

Sequence description from provider

RecName: Full=Interleukin-17 receptor A; Short=IL-17 receptor A; Short=IL-17RA;AltName: CD_antigen=CD217;Flags: Precursor;

Provider

SWISS-PROT

Sequence

Polypeptide 864 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Il17ra	interleukin 17 receptor A	39	98	3	19

Sequence references in MGI

J:30252 Yao Z, et al., Herpesvirus Saimiri encodes a new cytokine, IL-17, which binds to a novel cytokine receptor. Immunity. 1995 Dec;3(6):811-21
J:131634 Hsu HC, et al., Interleukin 17-producing T helper cells and interleukin 17 orchestrate autoreactive germinal center development in autoimmune BXD2 mice. Nat Immunol. 2008 Feb;9(2):166-75
J:143719 Ishigame H, et al., Differential roles of interleukin-17A and -17F in host defense against mucoepithelial bacterial infection and allergic responses. Immunity. 2009 Jan;30(1):108-19
J:153022 Kuestner RE, et al., Identification of the IL-17 receptor related molecule IL-17RC as the receptor for IL-17F. J Immunol. 2007 Oct 15;179(8):5462-73
J:161481 Cho JS, et al., IL-17 is essential for host defense against cutaneous Staphylococcus aureus infection in mice. J Clin Invest. 2010 May 3;120(5):1762-73
J:161934 Ho AW, et al., IL-17RC is required for immune signaling via an extended SEF/IL-17R signaling domain in the cytoplasmic tail. J Immunol. 2010 Jul 15;185(2):1063-70
J:177650 Chang SH, et al., Interleukin-17C Promotes Th17 Cell Responses and Autoimmune Disease via Interleukin-17 Receptor E. Immunity. 2011 Oct 28;35(4):611-21
J:178966 Song X, et al., IL-17RE is the functional receptor for IL-17C and mediates mucosal immunity to infection with intestinal pathogens. Nat Immunol. 2011 Dec;12(12):1151-8
J:178967 Ramirez-Carrozzi V, et al., IL-17C regulates the innate immune function of epithelial cells in an autocrine manner. Nat Immunol. 2011 Dec;12(12):1159-66
J:246922 Wang X, et al., IL-17A Promotes Pulmonary B-1a Cell Differentiation via Induction of Blimp-1 Expression during Influenza Virus Infection. PLoS Pathog. 2016 Jan;12(1):e1005367
J:251827 De Luca A, et al., The IL-17F/IL-17RC Axis Promotes Respiratory Allergy in the Proximal Airways. Cell Rep. 2017 Aug 15;20(7):1667-1680
J:264984 Acharya D, et al., Interleukin-17A Promotes CD8+ T Cell Cytotoxicity To Facilitate West Nile Virus Clearance. J Virol. 2017 Jan 1;91(1)
J:266885 Chen K, et al., IL-17 Receptor Signaling in the Lung Epithelium Is Required for Mucosal Chemokine Gradients and Pulmonary Host Defense against K. pneumoniae. Cell Host Microbe. 2016 Nov 9;20(5):596-605
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:304178 Lin X, et al., ORF8 contributes to cytokine storm during SARS-CoV-2 infection by activating IL-17 pathway. iScience. 2021 Apr 23;24(4):102293