Sequence Detail

ID/Version

Q61160 Q61082 Q3TC37 (UniProt | EBI)

Last sequence update: 1997-11-01
Last annotation update: 2024-07-24

Sequence description from provider

RecName: Full=FAS-associated death domain protein {ECO:0000303|PubMed:8649383};AltName: Full=FAS-associating death domain-containing protein {ECO:0000303|PubMed:8649383};AltName: Full=Mediator of receptor induced toxicity {ECO:0000303|PubMed:8649383};

Provider

SWISS-PROT

Sequence

Polypeptide 205 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Fadd	Fas associated via death domain	115	107	3	16

Sequence references in MGI

J:33049 Zhang J, et al., A mouse Fas-associated protein with homology to the human Mort1/FADD protein is essential for Fas-induced apoptosis. Mol Cell Biol. 1996 Jun;16(6):2756-63
J:38183 Hsu H, et al., TRADD-TRAF2 and TRADD-FADD interactions define two distinct TNF receptor 1 signal transduction pathways. Cell. 1996 Jan 26;84(2):299-308
J:55358 Jeong EJ, et al., The solution structure of FADD death domain. Structural basis of death domain interactions of Fas and FADD. J Biol Chem. 1999 Jun 4;274(23):16337-42
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:217283 Nam YJ, et al., Inhibition of both the extrinsic and intrinsic death pathways through nonhomotypic death-fold interactions. Mol Cell. 2004 Sep 24;15(6):901-12
J:251915 Geng J, et al., Regulation of RIPK1 activation by TAK1-mediated phosphorylation dictates apoptosis and necroptosis. Nat Commun. 2017 Aug 25;8(1):359
J:265780 Meng H, et al., Death-domain dimerization-mediated activation of RIPK1 controls necroptosis and RIPK1-dependent apoptosis. Proc Natl Acad Sci U S A. 2018 Feb 27;115(9):E2001-E2009
J:279494 Tang Y, et al., K63-linked ubiquitination regulates RIPK1 kinase activity to prevent cell death during embryogenesis and inflammation. Nat Commun. 2019 Sep 13;10(1):4157
J:281201 Anderton H, et al., RIPK1 prevents TRADD-driven, but TNFR1 independent, apoptosis during development. Cell Death Differ. 2019 May;26(5):877-889
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89