Sequence Detail

ID/Version

Q61176 Q3TB74 Q3UEL0 Q4FK78 Q80VI4 (UniProt | EBI)

Last sequence update: 1997-11-01
Last annotation update: 2024-11-27

Sequence description from provider

RecName: Full=Arginase-1; EC=3.5.3.1 {ECO:0000250|UniProtKB:P05089};AltName: Full=Liver-type arginase;AltName: Full=Type I arginase;

Provider

SWISS-PROT

Sequence

Polypeptide 323 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Arg1	arginase, liver	35	108	3	16

Sequence references in MGI

J:24482 Modolell M, et al., Reciprocal regulation of the nitric oxide synthase/arginase balance in mouse bone marrow-derived macrophages by TH1 and TH2 cytokines. Eur J Immunol. 1995 Apr;25(4):1101-4
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:161215 Herbert DR, et al., Arginase I suppresses IL-12/IL-23p40-driven intestinal inflammation during acute schistosomiasis. J Immunol. 2010 Jun 1;184(11):6438-46
J:191717 Narita Y, et al., The Key Role of IL-6-Arginase Cascade for Inducing Dendritic Cell-Dependent CD4+ T Cell Dysfunction in Tumor-Bearing Mice. J Immunol. 2013 Jan 15;190(2):812-20
J:200558 Barron L, et al., Role of arginase 1 from myeloid cells in th2-dominated lung inflammation. PLoS One. 2013;8(4):e61961
J:202409 Campbell L, et al., Local arginase 1 activity is required for cutaneous wound healing. J Invest Dermatol. 2013 Oct;133(10):2461-70
J:203468 Park J, et al., SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways. Mol Cell. 2013 Jun 27;50(6):919-30
J:243399 Pesce JT, et al., Arginase-1-expressing macrophages suppress Th2 cytokine-driven inflammation and fibrosis. PLoS Pathog. 2009 Apr;5(4):e1000371
J:289783 Monticelli LA, et al., Arginase 1 is an innate lymphoid-cell-intrinsic metabolic checkpoint controlling type 2 inflammation. Nat Immunol. 2016 Jun;17(6):656-65
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89