Sequence Detail

ID/Version

Q61216 Q62430 (UniProt | EBI)

Last sequence update: 1996-11-01
Last annotation update: 2024-11-27

Sequence description from provider

RecName: Full=Double-strand break repair protein MRE11 {ECO:0000305}; EC=3.1.-.- {ECO:0000269|PubMed:18854157};AltName: Full=Meiotic recombination 11 homolog 1; Short=MRE11 homolog 1;AltName: Full=Meiotic recombination 11 homolog A;

Provider

SWISS-PROT

Sequence

Polypeptide 706 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Mre11a	MRE11A homolog A, double strand break repair nuclease	92	99	3	32

Sequence references in MGI

J:42675 Xiao Y, et al., Conditional gene targeted deletion by Cre recombinase demonstrates the requirement for the double-strand break repair Mre11 protein in murine embryonic stem cells. Nucleic Acids Res. 1997 Aug 1;25(15):2985-91
J:87088 Theunissen JW, et al., Checkpoint failure and chromosomal instability without lymphomagenesis in Mre11(ATLD1/ATLD1) mice. Mol Cell. 2003 Dec;12(6):1511-23
J:120745 Cherry SM, et al., The Mre11 complex influences DNA repair, synapsis, and crossing over in murine meiosis. Curr Biol. 2007 Feb 20;17(4):373-8
J:147247 Buis J, et al., Mre11 nuclease activity has essential roles in DNA repair and genomic stability distinct from ATM activation. Cell. 2008 Oct 3;135(1):85-96
J:265834 Hung PJ, et al., MRI Is a DNA Damage Response Adaptor during Classical Non-homologous End Joining. Mol Cell. 2018 Jul 19;71(2):332-342.e8
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:349030 Cho MG, et al., MRE11 liberates cGAS from nucleosome sequestration during tumorigenesis. Nature. 2024 Jan;625(7995):585-592