Sequence Detail

ID/Version

Q61221 Q8R385 O08741 Q8C681 Q8CC19 Q61664 Q61665 Q8CCB6 Q9CYA8 O08993 (UniProt | EBI)

Last sequence update: 2003-07-03
Last annotation update: 2024-07-24

Sequence description from provider

RecName: Full=Hypoxia-inducible factor 1-alpha; Short=HIF-1-alpha; Short=HIF1-alpha;AltName: Full=ARNT-interacting protein;

Provider

SWISS-PROT

Sequence

Polypeptide 836 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Hif1a	hypoxia inducible factor 1, alpha subunit	238	153	4	29

Sequence references in MGI

J:33500 Wenger RH, et al., Nucleotide sequence, chromosomal assignment and mRNA expression of mouse hypoxia-inducible factor-1 alpha. Biochem Biophys Res Commun. 1996 Jun 5;223(1):54-9
J:35141 Li H, et al., Induction of phosphoglycerate kinase 1 gene expression by hypoxia. Roles of Arnt and HIF1alpha. J Biol Chem. 1996 Aug 30;271(35):21262-7
J:41006 Wenger RH, et al., The mouse gene for hypoxia-inducible factor-1alpha--genomic organization, expression and characterization of an alternative first exon and 5' flanking sequence. Eur J Biochem. 1997 May 15;246(1):155-65
J:50438 Luo G, et al., Molecular characterization of the murine Hif-1 alpha locus. Gene Expr. 1997;6(5):287-99
J:91355 Shao R, et al., Increase of SUMO-1 expression in response to hypoxia: direct interaction with HIF-1alpha in adult mouse brain and heart in vivo. FEBS Lett. 2004 Jul 2;569(1-3):293-300
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:110340 Hagele S, et al., TSGA10 prevents nuclear localization of the hypoxia-inducible factor (HIF)-1alpha. FEBS Lett. 2006 Jun 26;580(15):3731-8
J:141453 Cheng J, et al., SUMO-specific protease 1 is essential for stabilization of HIF1alpha during hypoxia. Cell. 2007 Nov 2;131(3):584-95
J:203396 Torii S, et al., Pro-apoptotic activity of inhibitory PAS domain protein (IPAS), a negative regulator of HIF-1, through binding to pro-survival Bcl-2 family proteins. Cell Death Differ. 2011 Nov;18(11):1711-25
J:210293 Shan B, et al., RSUME is implicated in HIF-1-induced VEGF-A production in pituitary tumour cells. Endocr Relat Cancer. 2012 Feb;19(1):13-27
J:247431 Wu D, et al., Structural integration in hypoxia-inducible factors. Nature. 2015 Aug 20;524(7565):303-8