Sequence Detail

ID/Version

Q61321 Q61323 Q61322 B2RQH3 (UniProt | EBI)

Last sequence update: 1996-11-01
Last annotation update: 2024-07-24

Sequence description from provider

RecName: Full=Homeobox protein SIX4;AltName: Full=Sine oculis homeobox homolog 4;AltName: Full=Skeletal muscle-specific ARE-binding protein AREC3;

Provider

SWISS-PROT

Sequence

Polypeptide 775 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Six4	sine oculis-related homeobox 4	52	112	4	8

Sequence references in MGI

J:31713 Kawakami K, et al., Structure, function and expression of a murine homeobox protein AREC3, a homologue of Drosophila sine oculis gene product, and implication in development. Nucleic Acids Res. 1996 Jan 15;24(2):303-10
J:52918 Niiya A, et al., Localization of Six4/AREC3 in the developing mouse retina; implications in mammalian retinal development. Exp Eye Res. 1998;67:699-707
J:69010 Ozaki H, et al., Six4, a putative myogenin gene regulator, is not essential for mouse embryonal development. Mol Cell Biol. 2001 May;21(10):3343-50
J:88186 Himeda CL, et al., Quantitative proteomic identification of six4 as the trex-binding factor in the muscle creatine kinase enhancer. Mol Cell Biol. 2004 Mar;24(5):2132-43
J:98519 Grifone R, et al., Six1 and Six4 homeoproteins are required for Pax3 and Mrf expression during myogenesis in the mouse embryo. Development. 2005 May;132(9):2235-49
J:103002 Ando Z, et al., Slc12a2 is a direct target of two closely related homeobox proteins, Six1 and Six4. FEBS J. 2005 Jun;272(12):3026-41
J:108725 Zou D, et al., Patterning of the third pharyngeal pouch into thymus/parathyroid by Six and Eya1. Dev Biol. 2006 May 15;293(2):499-512
J:113793 Ohto H, et al., Cooperation of six and eya in activation of their target genes through nuclear translocation of Eya. Mol Cell Biol. 1999 Oct;19(10):6815-24
J:114468 Konishi Y, et al., Six1 and Six4 promote survival of sensory neurons during early trigeminal gangliogenesis. Brain Res. 2006 Oct 20;1116(1):93-102
J:122815 Giordani J, et al., Six proteins regulate the activation of Myf5 expression in embryonic mouse limbs. Proc Natl Acad Sci U S A. 2007 Jul 3;104(27):11310-11315
J:145187 Chen B, et al., Initiation of olfactory placode development and neurogenesis is blocked in mice lacking both Six1 and Six4. Dev Biol. 2009 Feb 1;326(1):75-85
J:156719 Niro C, et al., Six1 and Six4 gene expression is necessary to activate the fast-type muscle gene program in the mouse primary myotome. Dev Biol. 2010 Feb 15;338(2):168-82
J:163483 He G, et al., Inactivation of Six2 in mouse identifies a novel genetic mechanism controlling development and growth of the cranial base. Dev Biol. 2010 Aug 15;344(2):720-30
J:165033 Yajima H, et al., Six family genes control the proliferation and differentiation of muscle satellite cells. Exp Cell Res. 2010 Oct 15;316(17):2932-44
J:172983 Kobayashi H, et al., Six1 and Six4 are essential for Gdnf expression in the metanephric mesenchyme and ureteric bud formation, while Six1 deficiency alone causes mesonephric-tubule defects. Mech Dev. 2007 Apr;124(4):290-303
J:178379 Richard AF, et al., Genesis of muscle fiber-type diversity during mouse embryogenesis relies on Six1 and Six4 gene expression. Dev Biol. 2011 Nov 15;359(2):303-20
J:190431 Suzuki Y, et al., Development of gustatory papillae in the absence of Six1 and Six4. J Anat. 2011 Dec;219(6):710-21
J:204550 Fujimoto Y, et al., Homeoproteins Six1 and Six4 regulate male sex determination and mouse gonadal development. Dev Cell. 2013 Aug 26;26(4):416-30
J:212814 Ikeda K, et al., Molecular interaction and synergistic activation of a promoter by Six, Eya, and Dach proteins mediated through CREB binding protein. Mol Cell Biol. 2002 Oct;22(19):6759-66