Sequence Detail

ID/Version

Q61371 Q3UXY9 E9QKU0 Q921J5 (UniProt | EBI)

Last sequence update: 2011-07-27
Last annotation update: 2024-11-27

Sequence description from provider

RecName: Full=Intraflagellar transport protein 88 homolog;AltName: Full=Recessive polycystic kidney disease protein Tg737;AltName: Full=Tetratricopeptide repeat protein 10; Short=TPR repeat protein 10;AltName: Full=TgN(Imorpk)737Rpw;

Provider

SWISS-PROT

Sequence

Polypeptide 824 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Ift88	intraflagellar transport 88	114	116	3	15

Sequence references in MGI

J:18508 Moyer JH, et al., Candidate gene associated with a mutation causing recessive polycystic kidney disease in mice. Science. 1994 May 27;264(5163):1329-33
J:65500 Pazour GJ, et al., Chlamydomonas IFT88 and its mouse homologue, polycystic kidney disease gene tg737, are required for assembly of cilia and flagella. J Cell Biol. 2000 Oct 30;151(3):709-18
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:119719 Hou Y, et al., Functional analysis of an individual IFT protein: IFT46 is required for transport of outer dynein arms into flagella. J Cell Biol. 2007 Feb 26;176(5):653-65
J:154656 Follit JA, et al., Characterization of mouse IFT complex B. Cell Motil Cytoskeleton. 2009 Aug;66(8):457-68
J:161171 Singla V, et al., Ofd1, a human disease gene, regulates the length and distal structure of centrioles. Dev Cell. 2010 Mar 16;18(3):410-24
J:182871 Lai CK, et al., Functional characterization of putative cilia genes by high-content analysis. Mol Biol Cell. 2011 Apr;22(7):1104-19
J:203423 Pampliega O, et al., Functional interaction between autophagy and ciliogenesis. Nature. 2013 Oct 10;502(7470):194-200
J:203626 Howard PW, et al., Interaction of mouse TTC30/DYF-1 with multiple intraflagellar transport complex B proteins and KIF17. Exp Cell Res. 2013 Aug 15;319(14):2275-81
J:206657 Ye X, et al., C2cd3 is critical for centriolar distal appendage assembly and ciliary vesicle docking in mammals. Proc Natl Acad Sci U S A. 2014 Feb 11;111(6):2164-9
J:207249 Wang C, et al., Centrosomal protein DZIP1 regulates Hedgehog signaling by promoting cytoplasmic retention of transcription factor GLI3 and affecting ciliogenesis. J Biol Chem. 2013 Oct 11;288(41):29518-29
J:207807 Kodani A, et al., Kif3a interacts with Dynactin subunit p150 Glued to organize centriole subdistal appendages. EMBO J. 2013 Feb 20;32(4):597-607
J:265626 Zhang Z, et al., Intraflagellar transport protein IFT20 is essential for male fertility and spermiogenesis in mice. Mol Biol Cell. 2016 Sep 28;
J:282613 Hilgendorf KI, et al., Omega-3 Fatty Acids Activate Ciliary FFAR4 to Control Adipogenesis. Cell. 2019 Nov 27;179(6):1289-1305.e21
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:307591 Wu B, et al., Essential Role of CFAP53 in Sperm Flagellum Biogenesis. Front Cell Dev Biol. 2021;9:676910
J:325559 Zhang R, et al., CCDC38 is required for sperm flagellum biogenesis and male fertility in mice. Development. 2022 Jun 1;149(11):dev200516
J:344445 Ma Y, et al., CCDC146 is required for sperm flagellum biogenesis and male fertility in mice. Cell Mol Life Sci. 2023 Dec 1;81(1):1