Sequence Detail

ID/Version

Q61412 (UniProt | EBI)

Last sequence update: 1996-11-01
Last annotation update: 2024-07-24

Sequence description from provider

RecName: Full=Visual system homeobox 2;AltName: Full=Ceh-10 homeodomain-containing homolog;AltName: Full=Homeobox protein CHX10;

Provider

SWISS-PROT

Sequence

Polypeptide 361 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Vsx2	visual system homeobox 2	25	160	3	16

Sequence references in MGI

J:19939 Liu IS, et al., Developmental expression of a novel murine homeobox gene (Chx10): evidence for roles in determination of the neuroretina and inner nuclear layer. Neuron. 1994 Aug;13(2):377-93
J:32083 Burmeister M, et al., Ocular retardation mouse caused by Chx10 homeobox null allele: impaired retinal progenitor proliferation and bipolar cell differentiation. Nat Genet. 1996 Apr;12(4):376-84
J:107659 Livne-Bar I, et al., Chx10 is required to block photoreceptor differentiation but is dispensable for progenitor proliferation in the postnatal retina. Proc Natl Acad Sci U S A. 2006 Mar 28;103(13):4988-93
J:131879 Clark AM, et al., Negative regulation of Vsx1 by its paralog Chx10/Vsx2 is conserved in the vertebrate retina. Brain Res. 2008 Feb 4;1192:99-113
J:135151 Sigulinsky CL, et al., Vsx2/Chx10 ensures the correct timing and magnitude of Hedgehog signaling in the mouse retina. Dev Biol. 2008 May 15;317(2):560-75
J:190452 Zou C, et al., Vsx2 controls eye organogenesis and retinal progenitor identity via homeodomain and non-homeodomain residues required for high affinity DNA binding. PLoS Genet. 2012 Sep;8(9):e1002924
J:238975 Clovis YM, et al., Chx10 Consolidates V2a Interneuron Identity through Two Distinct Gene Repression Modes. Cell Rep. 2016 Aug 09;16(6):1642-52
J:328860 Lee S, et al., A regulatory network to segregate the identity of neuronal subtypes. Dev Cell. 2008 Jun;14(6):877-89