Sequence Detail

ID/Version

Q61425 Q3TF75 Q8K149 Q3THK8 Q3UFI0 Q925U9 (UniProt | EBI)

Last sequence update: 2002-06-06
Last annotation update: 2024-11-27

Sequence description from provider

RecName: Full=Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial; Short=HCDH; EC=1.1.1.35 {ECO:0000250|UniProtKB:P00348};AltName: Full=Medium and short-chain L-3-hydroxyacyl-coenzyme A dehydrogenase {ECO:0000303|Ref.2};AltName: Full=Short

Provider

SWISS-PROT

Sequence

Polypeptide 314 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Hadh	hydroxyacyl-Coenzyme A dehydrogenase	37	101	3	13

Sequence references in MGI

J:28076 Nomura M, et al., Isolation of a cDNA clone encoding mouse 3-hydroxyacyl CoA dehydrogenase. Gene. 1995 Jul 28;160(2):309-10
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:166803 Li C, et al., Mechanism of hyperinsulinism in short-chain 3-hydroxyacyl-CoA dehydrogenase deficiency involves activation of glutamate dehydrogenase. J Biol Chem. 2010 Oct 8;285(41):31806-18
J:196142 Rardin MJ, et al., Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways. Proc Natl Acad Sci U S A. 2013 Apr 16;110(16):6601-6
J:203468 Park J, et al., SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways. Mol Cell. 2013 Jun 27;50(6):919-30
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:333351 Zhu H, et al., Hadh deficiency induced oligoasthenoteratozoospermia through the TNF-alpha/Bcl-2 pathway in male mice. FASEB J. 2022 Dec;36(12):e22661