Sequence Detail

ID/Version

Q61554 Q60826 A2AQ53 (UniProt | EBI)

Last sequence update: 2016-07-06
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Fibrillin-1 {ECO:0000250|UniProtKB:P35555};Contains: RecName: Full=Asprosin {ECO:0000250|UniProtKB:P35555};Flags: Precursor;

Provider

SWISS-PROT

Sequence

Polypeptide 2873 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Fbn1	fibrillin 1	65	115	3	28

Sequence references in MGI

J:22526 Yin W, et al., Primary structure and developmental expression of Fbn-1, the mouse fibrillin gene. J Biol Chem. 1995 Jan 27;270(4):1798-806
J:110586 Carta L, et al., Fibrillins 1 and 2 perform partially overlapping functions during aortic development. J Biol Chem. 2006 Mar 24;281(12):8016-23
J:160041 Tsutsui K, et al., ADAMTSL-6 is a novel extracellular matrix protein that binds to fibrillin-1 and promotes fibrillin-1 fibril formation. J Biol Chem. 2010 Feb 12;285(7):4870-82
J:165256 Nistala H, et al., Fibrillin-1 and -2 differentially modulate endogenous TGF-beta and BMP bioavailability during bone formation. J Cell Biol. 2010 Sep 20;190(6):1107-21
J:234498 Romere C, et al., Asprosin, a Fasting-Induced Glucogenic Protein Hormone. Cell. 2016 Apr 21;165(3):566-79
J:235251 Tiedemann K, et al., Fibrillin-1 directly regulates osteoclast formation and function by a dual mechanism. J Cell Sci. 2013 Sep 15;126(Pt 18):4187-94
J:251851 Duerrschmid C, et al., Asprosin is a centrally acting orexigenic hormone. Nat Med. 2017 Dec;23(12):1444-1453
J:279017 Li E, et al., OLFR734 Mediates Glucose Metabolism as a Receptor of Asprosin. Cell Metab. 2019 Aug 6;30(2):319-328.e8
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:313846 Jung TW, et al., Asprosin attenuates insulin signaling pathway through PKCdelta-activated ER stress and inflammation in skeletal muscle. J Cell Physiol. 2019 Nov;234(11):20888-20899
J:314392 Wei F, et al., The Asprosin-OLFR734 hormonal signaling axis modulates male fertility. Cell Discov. 2019;5:55
J:314912 Miao Y, et al., Novel adipokine asprosin modulates browning and adipogenesis in white adipose tissue. J Endocrinol. 2021 May;249(2):83-93
J:319868 Liu Y, et al., The Asprosin-OLFR734 module regulates appetitive behaviors. Cell Discov. 2020;6:19
J:349367 Mishra I, et al., Asprosin-neutralizing antibodies as a treatment for metabolic syndrome. Elife. 2021 Apr 27;10