Sequence Detail

ID/Version

Q61572 O88409 Q61582 Q9QWR9 (UniProt | EBI)

Last sequence update: 2011-07-27
Last annotation update: 2024-11-27

Sequence description from provider

RecName: Full=Forkhead box protein C1;AltName: Full=Forkhead-related protein FKHL7;AltName: Full=Forkhead-related transcription factor 3; Short=FREAC-3;AltName: Full=Mesoderm/mesenchyme forkhead 1; Short=MF-1;AltName: Full=Transcription fa

Provider

SWISS-PROT

Sequence

Polypeptide 553 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Foxc1	forkhead box C1	117	150	4	9

Sequence references in MGI

J:11921 Sasaki H, et al., Differential expression of multiple fork head related genes during gastrulation and axial pattern formation in the mouse embryo. Development. 1993 May;118(1):47-59
J:14165 Kaestner KH, et al., Six members of the mouse forkhead gene family are developmentally regulated. Proc Natl Acad Sci U S A. 1993 Aug 15;90(16):7628-31
J:39636 Winnier GE, et al., The winged helix transcription factor MFH1 is required for proliferation and patterning of paraxial mesoderm in the mouse embryo. Genes Dev. 1997 Apr 1;11(7):926-40
J:48079 Kume T, et al., The forkhead/winged helix gene Mf1 is disrupted in the pleiotropic mouse mutation congenital hydrocephalus. Cell. 1998 Jun 12;93(6):985-96
J:50469 Hiemisch H, et al., The mouse Fkh1/Mf1 gene: cDNA sequence, chromosomal localization and expression in adult tissues. Gene. 1998 Oct 5;220(1-2):77-82
J:56425 Kidson SH, et al., The forkhead/winged-helix gene, Mf1, is necessary for the normal development of the cornea and formation of the anterior chamber in the mouse eye. Dev Biol. 1999 Jul 15;211(2):306-22
J:57677 Winnier GE, et al., Roles for the winged helix transcription factors MF1 and MFH1 in cardiovascular development revealed by nonallelic noncomplementation of null alleles. Dev Biol. 1999 Sep 15;213(2):418-31
J:60834 Kume T, et al., Murine forkhead/winged helix genes Foxc1 (Mf1) and Foxc2 (Mfh1) are required for the early organogenesis of the kidney and urinary tract. Development. 2000 Apr;127(7):1387-95
J:71693 Kume T, et al., The murine winged helix transcription factors, Foxc1 and Foxc2, are both required for cardiovascular development and somitogenesis. Genes Dev. 2001 Sep 15;15(18):2470-82
J:91443 Wilm B, et al., The forkhead genes, Foxc1 and Foxc2, regulate paraxial versus intermediate mesoderm cell fate. Dev Biol. 2004 Jul 1;271(1):176-89
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:131323 Hayashi H, et al., Forkhead transcription factors regulate expression of the chemokine receptor CXCR4 in endothelial cells and CXCL12-induced cell migration. Biochem Biophys Res Commun. 2008 Mar 14;367(3):584-9
J:152710 Aldinger KA, et al., FOXC1 is required for normal cerebellar development and is a major contributor to chromosome 6p25.3 Dandy-Walker malformation. Nat Genet. 2009 Sep;41(9):1037-42
J:181974 Seo S, et al., Forkhead box transcription factor FoxC1 preserves corneal transparency by regulating vascular growth. Proc Natl Acad Sci U S A. 2012 Feb 7;109(6):2015-20
J:210256 Omatsu Y, et al., Foxc1 is a critical regulator of haematopoietic stem/progenitor cell niche formation. Nature. 2014 Apr 24;508(7497):536-40
J:221866 Yoshida M, et al., The transcription factor Foxc1 is necessary for Ihh-Gli2-regulated endochondral ossification. Nat Commun. 2015;6:6653
J:228951 Han B, et al., FOXC1 Activates Smoothened-Independent Hedgehog Signaling in Basal-like Breast Cancer. Cell Rep. 2015 Nov 3;13(5):1046-58
J:240396 Motojima M, et al., Foxc1 and Foxc2 are necessary to maintain glomerular podocytes. Exp Cell Res. 2017 Mar 15;352(2):265-272
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89