ID/Version |
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Sequence description from provider |
RecName: Full=RNA-binding protein FXR1 {ECO:0000305}; Short=FXR1P {ECO:0000303|PubMed:22022532}; Short=mFxr1p {ECO:0000303|PubMed:11438699}; | ||||||||||||||
Provider | SWISS-PROT | ||||||||||||||
Sequence |
Polypeptide
677
aa
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Annotated genes and markers |
Follow the symbol links to get more information on the GO terms,
expression assays, orthologs, phenotypic alleles, and other information
for the genes or markers below.
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Sequence references in MGI |
J:30134
Coy JF, et al., Highly conserved 3' UTR and expression pattern of FXR1 points to a divergent gene regulation of FXR1 and FMR1. Hum Mol Genet. 1995 Dec;4(12):2209-18
J:56616 Kirkpatrick LL, et al., Alternative splicing in the murine and human FXR1 genes. Genomics. 1999 Jul 15;59(2):193-202 J:88664 Schenck A, et al., A highly conserved protein family interacting with the fragile X mental retardation protein (FMRP) and displaying selective interactions with FMRP-related proteins FXR1P and FXR2P. Proc Natl Acad Sci U S A. 2001 Jul 17;98(15):8844-9 J:91191 Mientjes EJ, et al., Fxr1 knockout mice show a striated muscle phenotype: implications for Fxr1p function in vivo. Hum Mol Genet. 2004 Jul 1;13(13):1291-302 J:96927 Garnon J, et al., Fragile X-related protein FXR1P regulates proinflammatory cytokine tumor necrosis factor expression at the post-transcriptional level. J Biol Chem. 2005 Feb 18;280(7):5750-63 J:103915 Huot ME, et al., The RNA-binding protein fragile X-related 1 regulates somite formation in Xenopus laevis. Mol Biol Cell. 2005 Sep;16(9):4350-61 J:179583 Cook D, et al., Fragile X related protein 1 clusters with ribosomes and messenger RNAs at a subset of dendritic spines in the mouse hippocampus. PLoS One. 2011;6(10):e26120 J:218753 Cook D, et al., FXR1P limits long-term memory, long-lasting synaptic potentiation, and de novo GluA2 translation. Cell Rep. 2014 Nov 20;9(4):1402-16 J:242048 Patzlaff NE, et al., Fragile X related protein 1 (FXR1P) regulates proliferation of adult neural stem cells. Hum Mol Genet. 2017 Apr 01;26(7):1340-1352 J:255973 Qie S, et al., Fbxo4-mediated degradation of Fxr1 suppresses tumorigenesis in head and neck squamous cell carcinoma. Nat Commun. 2017 Nov 16;8(1):1534 J:263376 Trinidad JC, et al., Comprehensive identification of phosphorylation sites in postsynaptic density preparations. Mol Cell Proteomics. 2006 May;5(5):914-22 J:263455 Wang GX, et al., Sub-synaptic, multiplexed analysis of proteins reveals Fragile X related protein 2 is mislocalized in Fmr1 KO synapses. Elife. 2016 Oct 22;5:e20560 J:276784 Estan MC, et al., Recessive mutations in muscle-specific isoforms of FXR1 cause congenital multi-minicore myopathy. Nat Commun. 2019 Feb 15;10(1):797 J:291328 Smith JA, et al., FXR1 splicing is important for muscle development and biomolecular condensates in muscle cells. J Cell Biol. 2020 Apr 6;219(4) J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89 J:305336 Khlghatyan J, et al., Fxr1 regulates sleep and synaptic homeostasis. EMBO J. 2020 Nov 2;39(21):e103864 J:332641 Kang JY, et al., LLPS of FXR1 drives spermiogenesis by activating translation of stored mRNAs. Science. 2022 Aug 12;377(6607):eabj6647 J:332980 Del'Guidice T, et al., FXR1P is a GSK3beta substrate regulating mood and emotion processing. Proc Natl Acad Sci U S A. 2015 Aug 18;112(33):E4610-9 |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 08/02/2024 MGI 6.24 |
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