ID/Version |
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Sequence description from provider |
RecName: Full=Transcriptional activator GLI3;AltName: Full=GLI3 form of 190 kDa; Short=GLI3-190;AltName: Full=GLI3 full-length protein; Short=GLI3FL;Contains: RecName: Full=Transcriptional repressor GLI3R; AltName: Full=GLI3 C-terminally | ||||||||||||||
Provider | SWISS-PROT | ||||||||||||||
Sequence |
Polypeptide
1583
aa
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Source | |||||||||||||||
Annotated genes and markers |
Follow the symbol links to get more information on the GO terms,
expression assays, orthologs, phenotypic alleles, and other information
for the genes or markers below.
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Sequence references in MGI |
J:11318
Pohl TM, et al., Evidence for allelism of the recessive insertional mutation add and the dominant mouse mutation extra-toes (Xt). Development. 1990 Dec;110(4):1153-7
J:34147 Thien H, et al., Cloning and sequence analysis of the murine Gli3 cDNA. Biochim Biophys Acta. 1996 Jul 17;1307(3):267-9 J:53808 Thien H, et al., The mouse mutation Pdn (Polydactyly Nagoya) is caused by the integration of a retrotransposon into the Gli3 gene. Mamm Genome. 1999 Mar;10(3):205-9 J:60639 Wang B, et al., Hedgehog-regulated processing of Gli3 produces an anterior/posterior repressor gradient in the developing vertebrate limb. Cell. 2000 Feb 18;100(4):423-34 J:121609 Wang C, et al., The Shh-independent activator function of the full-length Gli3 protein and its role in vertebrate limb digit patterning. Dev Biol. 2007 May 15;305(2):460-9 J:149459 Wuelling M, et al., Trps1, a regulator of chondrocyte proliferation and differentiation, interacts with the activator form of Gli3. Dev Biol. 2009 Apr 1;328(1):40-53 J:152259 Cheung HO, et al., The kinesin protein Kif7 is a critical regulator of Gli transcription factors in mammalian hedgehog signaling. Sci Signal. 2009;2(76):ra29 J:152551 Endoh-Yamagami S, et al., The mammalian Cos2 homolog Kif7 plays an essential role in modulating Hh signal transduction during development. Curr Biol. 2009 Aug 11;19(15):1320-6 J:158961 Humke EW, et al., The output of Hedgehog signaling is controlled by the dynamic association between Suppressor of Fused and the Gli proteins. Genes Dev. 2010 Apr 1;24(7):670-82 J:169807 Mizugishi K, et al., Molecular properties of Zic proteins as transcriptional regulators and their relationship to GLI proteins. J Biol Chem. 2001 Jan 19;276(3):2180-8 J:207249 Wang C, et al., Centrosomal protein DZIP1 regulates Hedgehog signaling by promoting cytoplasmic retention of transcription factor GLI3 and affecting ciliogenesis. J Biol Chem. 2013 Oct 11;288(41):29518-29 J:257035 Kim YJ, et al., WDR11-mediated Hedgehog signalling defects underlie a new ciliopathy related to Kallmann syndrome. EMBO Rep. 2018 Feb;19(2):269-289 J:306378 Guo A, et al., Immunoaffinity enrichment and mass spectrometry analysis of protein methylation. Mol Cell Proteomics. 2014 Jan;13(1):372-87 |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 08/21/2024 MGI 6.24 |
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