Sequence Detail

ID/Version

Q61687 A2ADH4 (UniProt | EBI)

Last sequence update: 2011-07-27
Last annotation update: 2024-11-27

Sequence description from provider

RecName: Full=Transcriptional regulator ATRX; EC=3.6.4.12;AltName: Full=ATP-dependent helicase ATRX;AltName: Full=HP1 alpha-interacting protein;AltName: Full=HP1-BP38 protein;AltName: Full=Heterochromatin protein 2;AltName: Full=X-linked nuclear p

Provider

SWISS-PROT

Sequence

Polypeptide 2476 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Atrx	ATRX, chromatin remodeler	81	123	3	113

Sequence references in MGI

J:37212 Le Douarin B, et al., A possible involvement of TIF1 alpha and TIF1 beta in the epigenetic control of transcription by nuclear receptors. EMBO J. 1996 Dec 2;15(23):6701-15
J:47271 Picketts DJ, et al., Comparison of the human and murine ATRX gene identifies highly conserved, functionally important domains. Mamm Genome. 1998 May;9(5):400-3
J:125897 Nan X, et al., Interaction between chromatin proteins MECP2 and ATRX is disrupted by mutations that cause inherited mental retardation. Proc Natl Acad Sci U S A. 2007 Feb 20;104(8):2709-14
J:143718 Trost M, et al., The phagosomal proteome in interferon-gamma-activated macrophages. Immunity. 2009 Jan;30(1):143-54
J:158584 Kernohan KD, et al., ATRX partners with cohesin and MeCP2 and contributes to developmental silencing of imprinted genes in the brain. Dev Cell. 2010 Feb 16;18(2):191-202
J:160497 Wong LH, et al., ATRX interacts with H3.3 in maintaining telomere structural integrity in pluripotent embryonic stem cells. Genome Res. 2010 Mar;20(3):351-60
J:161214 Drane P, et al., The death-associated protein DAXX is a novel histone chaperone involved in the replication-independent deposition of H3.3. Genes Dev. 2010 Jun 15;24(12):1253-65
J:167956 Goldberg AD, et al., Distinct factors control histone variant H3.3 localization at specific genomic regions. Cell. 2010 Mar 5;140(5):678-91
J:205556 Christophorou MA, et al., Citrullination regulates pluripotency and histone H1 binding to chromatin. Nature. 2014 Mar 6;507(7490):104-8
J:209584 Clynes D, et al., ATRX dysfunction induces replication defects in primary mouse cells. PLoS One. 2014;9(3):e92915
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:306378 Guo A, et al., Immunoaffinity enrichment and mass spectrometry analysis of protein methylation. Mol Cell Proteomics. 2014 Jan;13(1):372-87