Sequence Detail

ID/Version

Q61955 Q8K5D7 (UniProt | EBI)

Last sequence update: 1996-11-01
Last annotation update: 2024-07-24

Sequence description from provider

RecName: Full=Kallikrein-8; Short=mK8; EC=3.4.21.118;AltName: Full=Neuropsin; Short=NP;AltName: Full=Serine protease 19;Flags: Precursor;

Provider

SWISS-PROT

Sequence

Polypeptide 260 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Klk8	kallikrein related-peptidase 8	20	105	2	5

Sequence references in MGI

J:26897 Chen ZL, et al., Expression and activity-dependent changes of a novel limbic-serine protease gene in the hippocampus. J Neurosci. 1995 Jul;15(7 Pt 2):5088-97
J:30685 Suzuki J, et al., Ontogeny of neuropsin mRNA expression in the mouse brain. Neurosci Res. 1995 Nov;23(4):345-51
J:34601 Okabe A, et al., Kindling induces neuropsin mRNA in the mouse brain. Brain Res. 1996 Jul 22;728(1):116-20
J:48104 Inoue N, et al., Expression of neuropsin in the keratinizing epithelial tissue-immunohistochemical analysis of wild-type and nude mice. J Invest Dermatol. 1998 Jun;110(6):923-31
J:57445 Yoshida S, et al., Assignment of the neuropsin gene (Prss19) to mouse chromosome band 7B4 by in situ hybridization. Cytogenet Cell Genet. 2000;88(1-2):97-8
J:68653 Hirata A, et al., Abnormalities of synapses and neurons in the hippocampus of neuropsin-deficient mice. Mol Cell Neurosci. 2001 Mar;17(3):600-10
J:71533 Davies B, et al., Loss of hippocampal serine protease BSP1/neuropsin predisposes to global seizure activity. J Neurosci. 2001 Sep 15;21(18):6993-7000
J:106989 Nakamura Y, et al., Role of neuropsin in formation and maturation of Schaffer-collateral L1cam-immunoreactive synaptic boutons. J Cell Sci. 2006 Apr 1;119(Pt 7):1341-9
J:120872 Kishibe M, et al., Kallikrein 8 is involved in skin desquamation in cooperation with other kallikreins. J Biol Chem. 2007 Feb 23;282(8):5834-41
J:128299 Terayama R, et al., Neuropsin promotes oligodendrocyte death, demyelination and axonal degeneration after spinal cord injury. Neuroscience. 2007 Aug 10;148(1):175-87
J:130005 Tamura H, et al., Neuropsin is essential for early processes of memory acquisition and Schaffer collateral long-term potentiation in adult mouse hippocampus in vivo. J Physiol. 2006 Feb 1;570(Pt 3):541-51
J:130007 Matsumoto-Miyai K, et al., NMDA-dependent proteolysis of presynaptic adhesion molecule L1 in the hippocampus by neuropsin. J Neurosci. 2003 Aug 27;23(21):7727-36
J:130010 Oka T, et al., Extracellular serine protease neuropsin (KLK8) modulates neurite outgrowth and fasciculation of mouse hippocampal neurons in culture. Neurosci Lett. 2002 Mar 22;321(3):141-4
J:130012 Kitayoshi H, et al., Effect of 12-O-tetradecanoyl-phorbol ester and incisional wounding on neuropsin mRNA and its protein expression in murine skin. Arch Dermatol Res. 1999 Jun;291(6):333-8
J:130013 Tomizawa K, et al., Injury induces neuropsin mRNA in the central nervous system. Brain Res. 1999 Apr 10;824(2):308-11
J:130015 Shimizu C, et al., Characterization of recombinant and brain neuropsin, a plasticity-related serine protease. J Biol Chem. 1998 May 1;273(18):11189-96
J:130032 He XP, et al., Expression of neuropsin in oligodendrocytes after injury to the CNS. Neurosci Res. 2001 Apr;39(4):455-62
J:164861 Scott FL, et al., SerpinB6 is an inhibitor of kallikrein-8 in keratinocytes. J Biochem. 2007 Oct;142(4):435-42