Sequence Detail

ID/Version

Q62070 Q62071 Q8R2P0 Q62072 A2AER1 (UniProt | EBI)

Last sequence update: 1996-11-01
Last annotation update: 2024-11-27

Sequence description from provider

RecName: Full=Serine/threonine-protein kinase pim-2; EC=2.7.11.1;

Provider

SWISS-PROT

Sequence

Polypeptide 370 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Pim2	proviral integration site 2	53	101	2	11

Sequence references in MGI

J:26138 van der Lugt NM, et al., Proviral tagging in E mu-myc transgenic mice lacking the Pim-1 proto-oncogene leads to compensatory activation of Pim-2. EMBO J. 1995 Jun 1;14(11):2536-44
J:42922 Allen JD, et al., Pim-2 transgene induces lymphoid tumors, exhibiting potent synergy with c-myc. Oncogene. 1997 Sep 4;15(10):1133-41
J:84700 Fox CJ, et al., The serine/threonine kinase Pim-2 is a transcriptionally regulated apoptotic inhibitor. Genes Dev. 2003 Aug 1;17(15):1841-54
J:86593 Yan B, et al., The PIM-2 kinase phosphorylates BAD on serine 112 and reverses BAD-induced cell death. J Biol Chem. 2003 Nov 14;278(46):45358-67
J:91592 Mikkers H, et al., Mice deficient for all PIM kinases display reduced body size and impaired responses to hematopoietic growth factors. Mol Cell Biol. 2004 Jul;24(13):6104-15
J:93995 Hammerman PS, et al., Lymphocyte transformation by Pim-2 is dependent on nuclear factor-kappaB activation. Cancer Res. 2004 Nov 15;64(22):8341-8
J:95695 Fox CJ, et al., The Pim kinases control rapamycin-resistant T cell survival and activation. J Exp Med. 2005 Jan 17;201(2):259-66
J:98472 Hammerman PS, et al., Pim and Akt oncogenes are independent regulators of hematopoietic cell growth and survival. Blood. 2005 Jun 1;105(11):4477-83
J:153319 Bohensky J, et al., PIM-2 is an independent regulator of chondrocyte survival and autophagy in the epiphyseal growth plate. J Cell Physiol. 2007 Oct;213(1):246-51
J:177147 Zhang Y, et al., Pim kinase-dependent inhibition of c-Myc degradation. Oncogene. 2008 Aug 14;27(35):4809-19