Sequence Detail

ID/Version

Q62077 Q6P1G1 (UniProt | EBI)

Last sequence update: 2006-01-24
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 {ECO:0000305}; EC=3.1.4.11 {ECO:0000250|UniProtKB:P10686};AltName: Full=Phosphoinositide phospholipase C-gamma-1;AltName: Full=Phospholipase C-gamma-1; Short=P

Provider

SWISS-PROT

Sequence

Polypeptide 1302 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Plcg1	phospholipase C, gamma 1	86	109	3	12

Sequence references in MGI

J:27510 Reith AD, et al., Signal transduction by normal isoforms and W mutant variants of the Kit receptor tyrosine kinase. EMBO J. 1991 Sep;10(9):2451-9
J:40299 Dupont G, et al., Phospholipase C in mouse oocytes: characterization of beta and gamma isoforms and their possible involvement in sperm-induced Ca2+ spiking. Biochem J. 1996 Jun 1;316(Pt 2):583-91
J:76896 Bachmaier K, et al., Negative regulation of lymphocyte activation and autoimmunity by the molecular adaptor Cbl-b. Nature. 2000 Jan 13;403(6766):211-6
J:93595 Jeon MS, et al., Essential role of the E3 ubiquitin ligase Cbl-b in T cell anergy induction. Immunity. 2004 Aug;21(2):167-77
J:130626 Minichiello L, et al., Mechanism of TrkB-mediated hippocampal long-term potentiation. Neuron. 2002 Sep 26;36(1):121-37
J:151074 Fu G, et al., Themis controls thymocyte selection through regulation of T cell antigen receptor-mediated signaling. Nat Immunol. 2009 Aug;10(8):848-56
J:186446 Wang D, et al., Tespa1 is involved in late thymocyte development through the regulation of TCR-mediated signaling. Nat Immunol. 2012 Jun;13(6):560-8
J:243541 Song M, et al., Inositol 5'-phosphatase, SHIP1 interacts with phospholipase C-gamma1 and modulates EGF-induced PLC activity. Exp Mol Med. 2005 Jun 30;37(3):161-8
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89