Sequence Detail

ID/Version

Q62167 O09060 O09143 (UniProt | EBI)

Last sequence update: 2007-01-23
Last annotation update: 2024-11-27

Sequence description from provider

RecName: Full=ATP-dependent RNA helicase DDX3X; EC=3.6.4.13 {ECO:0000250|UniProtKB:O00571};AltName: Full=D1Pas1-related sequence 2;AltName: Full=DEAD box RNA helicase DEAD3; Short=mDEAD3 {ECO:0000303|PubMed:8144024};AltName: Full=DEAD box

Provider

SWISS-PROT

Sequence

Polypeptide 662 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Ddx3x	DEAD box helicase 3, X-linked	164	111	4	23

Sequence references in MGI

J:17429 Gee SL, et al., Mouse erythroid cells express multiple putative RNA helicase genes exhibiting high sequence conservation from yeast to mammals. Gene. 1994 Mar 25;140(2):171-7
J:26244 Sowden J, et al., The embryonic RNA helicase gene (ERH): a new member of the DEAD box family of RNA helicases. Biochem J. 1995 Jun 15;308(Pt 3):839-46
J:203468 Park J, et al., SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways. Mol Cell. 2013 Jun 27;50(6):919-30
J:231798 Chen CY, et al., Targeted inactivation of murine Ddx3x: essential roles of Ddx3x in placentation and embryogenesis. Hum Mol Genet. 2016 July 15;25(14):2905-2922
J:274336 Matsumura T, et al., An azoospermic factor gene, Ddx3y and its paralog, Ddx3x are dispensable in germ cells for male fertility. J Reprod Dev. 2019 Apr 12;65(2):121-128
J:279977 Samir P, et al., DDX3X acts as a live-or-die checkpoint in stressed cells by regulating NLRP3 inflammasome. Nature. 2019 Sep;573(7775):590-594
J:291333 Szappanos D, et al., The RNA helicase DDX3X is an essential mediator of innate antimicrobial immunity. PLoS Pathog. 2018 Nov;14(11):e1007397
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:306378 Guo A, et al., Immunoaffinity enrichment and mass spectrometry analysis of protein methylation. Mol Cell Proteomics. 2014 Jan;13(1):372-87