Sequence Detail

ID/Version

Q62226 (UniProt | EBI)

Last sequence update: 1998-06-01
Last annotation update: 2024-07-24

Sequence description from provider

RecName: Full=Sonic hedgehog protein {ECO:0000305}; Short=SHH; EC=3.1.-.- {ECO:0000269|PubMed:8824192};AltName: Full=HHG-1;AltName: Full=Shh unprocessed N-terminal signaling and C-terminal autoprocessing domains {ECO:0000303|PubMed:2452219

Provider

SWISS-PROT

Sequence

Polypeptide 437 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Shh	sonic hedgehog	370	763	4	49

Sequence references in MGI

J:16386 Echelard Y, et al., Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity. Cell. 1993 Dec 31;75(7):1417-30
J:21621 Chang DT, et al., Products, genetic linkage and limb patterning activity of a murine hedgehog gene. Development. 1994 Nov;120(11):3339-53
J:25028 Roelink H, et al., Floor plate and motor neuron induction by different concentrations of the amino-terminal cleavage product of sonic hedgehog autoproteolysis. Cell. 1995 May 5;81(3):445-55
J:71848 Bumcrot DA, et al., Proteolytic processing yields two secreted forms of sonic hedgehog. Mol Cell Biol. 1995 Apr;15(4):2294-303
J:82736 Charron F, et al., The Morphogen Sonic Hedgehog Is an Axonal Chemoattractant that Collaborates with Netrin-1 in Midline Axon Guidance. Cell. 2003 Apr 4;113(1):11-23
J:87181 Gold DA, et al., RORalpha coordinates reciprocal signaling in cerebellar development through sonic hedgehog and calcium-dependent pathways. Neuron. 2003 Dec 18;40(6):1119-31
J:89228 Chen MH, et al., Palmitoylation is required for the production of a soluble multimeric Hedgehog protein complex and long-range signaling in vertebrates. Genes Dev. 2004 Mar 15;18(6):641-59
J:92507 Ahn S, et al., Dynamic changes in the response of cells to positive hedgehog signaling during mouse limb patterning. Cell. 2004 Aug 20;118(4):505-16
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:130672 Abe Y, et al., Mammalian Gup1, a homolog of Saccharomyces cerevisiae glycerol uptake/transporter 1, acts as a negative regulator for N-terminal palmitoylation of Sonic hedgehog. FEBS J. 2008 Jan;275(2):318-31
J:135168 Capurro MI, et al., Glypican-3 inhibits Hedgehog signaling during development by competing with patched for Hedgehog binding. Dev Cell. 2008 May;14(5):700-11
J:175351 Bishop B, et al., Structural insights into hedgehog ligand sequestration by the human hedgehog-interacting protein HHIP. Nat Struct Mol Biol. 2009 Jul;16(7):698-703
J:245278 McLellan JS, et al., The mode of Hedgehog binding to Ihog homologues is not conserved across different phyla. Nature. 2008 Oct 16;455(7215):979-83
J:263426 Kavran JM, et al., All mammalian Hedgehog proteins interact with cell adhesion molecule, down-regulated by oncogenes (CDO) and brother of CDO (BOC) in a conserved manner. J Biol Chem. 2010 Aug 6;285(32):24584-90
J:326327 Porter JA, et al., Cholesterol modification of hedgehog signaling proteins in animal development. Science. 1996 Oct 11;274(5285):255-9