Sequence Detail

ID/Version

Q62293 Q8BN19 Q60711 (UniProt | EBI)

Last sequence update: 1996-11-01
Last annotation update: 2024-07-24

Sequence description from provider

RecName: Full=T-cell-specific guanine nucleotide triphosphate-binding protein 1; EC=3.6.5.- {ECO:0000269|PubMed:9725230};AltName: Full=Interferon-gamma-inducible GTPase Ifggb5 {ECO:0000303|PubMed:22892676};

Provider

SWISS-PROT

Sequence

Polypeptide 415 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Tgtp1	T cell specific GTPase 1	18	99	3	1

Sequence references in MGI

J:23604 Lafuse WP, et al., Cloning and characterization of a novel cDNA that is IFN-gamma-induced in mouse peritoneal macrophages and encodes a putative GTP-binding protein. J Leukoc Biol. 1995 Mar;57(3):477-83
J:42353 Carlow DA, et al., Isolation of a gene encoding a developmentally regulated T cell-specific protein with a guanine nucleotide triphosphate-binding motif. J Immunol. 1995 Feb 15;154(4):1724-34
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:113847 Carlow DA, et al., Specific antiviral activity demonstrated by TGTP, a member of a new family of interferon-induced GTPases. J Immunol. 1998 Sep 1;161(5):2348-55
J:144154 Bekpen C, et al., The interferon-inducible p47 (IRG) GTPases in vertebrates: loss of the cell autonomous resistance mechanism in the human lineage. Genome Biol. 2005;6(11):R92
J:145916 Zhao Y, et al., Virulent Toxoplasma gondii evade immunity-related GTPase-mediated parasite vacuole disruption within primed macrophages. J Immunol. 2009 Mar 15;182(6):3775-81
J:209893 Ohshima J, et al., Role of mouse and human autophagy proteins in IFN-gamma-induced cell-autonomous responses against Toxoplasma gondii. J Immunol. 2014 Apr 1;192(7):3328-35
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:333124 Khaminets A, et al., Coordinated loading of IRG resistance GTPases on to the Toxoplasma gondii parasitophorous vacuole. Cell Microbiol. 2010 Jul;12(7):939-61