Sequence Detail

ID/Version

Q62383 Q5SYM0 Q6GQS3 Q8BQY6 Q6ZQI0 (UniProt | EBI)

Last sequence update: 2004-08-31
Last annotation update: 2024-07-24

Sequence description from provider

RecName: Full=Transcription elongation factor SPT6;

Provider

SWISS-PROT

Sequence

Polypeptide 1726 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Supt6	SPT6, histone chaperone and transcription elongation factor	28	107	3	27

Sequence references in MGI

J:33852 Chiang PW, et al., Identification and analysis of the human and murine putative chromatin structure regulator SUPT6H and Supt6h. Genomics. 1996 Jun 15;34(3):328-33
J:86686 Okazaki N, et al., Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. DNA Res. 2003 Aug 31;10(4):167-80
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:172192 Okazaki IM, et al., Histone chaperone Spt6 is required for class switch recombination but not somatic hypermutation. Proc Natl Acad Sci U S A. 2011 May 10;108(19):7920-5
J:190400 Begum NA, et al., The histone chaperone Spt6 is required for activation-induced cytidine deaminase target determination through H3K4me3 regulation. J Biol Chem. 2012 Sep 21;287(39):32415-29
J:195534 Wang AH, et al., The histone chaperone Spt6 coordinates histone H3K27 demethylation and myogenesis. EMBO J. 2013 Apr 17;32(8):1075-86
J:200392 Yoh SM, et al., The Iws1:Spt6:CTD complex controls cotranscriptional mRNA biosynthesis and HYPB/Setd2-mediated histone H3K36 methylation. Genes Dev. 2008 Dec 15;22(24):3422-34
J:200417 Yoh SM, et al., The Spt6 SH2 domain binds Ser2-P RNAPII to direct Iws1-dependent mRNA splicing and export. Genes Dev. 2007 Jan 15;21(2):160-74
J:278445 Bi X, et al., RNA Targets Ribogenesis Factor WDR43 to Chromatin for Transcription and Pluripotency Control. Mol Cell. 2019 Jul 11;75(1):102-116.e9
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89