Sequence Detail

ID/Version

Q62386 Q60971 (UniProt | EBI)

Last sequence update: 1996-11-01
Last annotation update: 2024-07-24

Sequence description from provider

RecName: Full=Interleukin-17A; Short=IL-17; Short=IL-17A;AltName: Full=Cytotoxic T-lymphocyte-associated antigen 8; Short=CTLA-8;Flags: Precursor;

Provider

SWISS-PROT

Sequence

Polypeptide 158 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Il17a	interleukin 17A	58	96	3	29

Sequence references in MGI

J:31782 Yao Z, et al., Complete nucleotide sequence of the mouse CTLA8 gene. Gene. 1996 Feb 12;168(2):223-5
J:36139 Kennedy J, et al., Mouse IL-17: a cytokine preferentially expressed by alpha beta TCR + CD4-CD8-T cells. J Interferon Cytokine Res. 1996 Aug;16(8):611-7
J:112600 Park H, et al., A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17. Nat Immunol. 2005 Nov;6(11):1133-41
J:115922 Ivanov II, et al., The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells. Cell. 2006 Sep 22;126(6):1121-33
J:125735 Michel ML, et al., Identification of an IL-17-producing NK1.1(neg) iNKT cell population involved in airway neutrophilia. J Exp Med. 2007 May 14;204(5):995-1001
J:131634 Hsu HC, et al., Interleukin 17-producing T helper cells and interleukin 17 orchestrate autoreactive germinal center development in autoimmune BXD2 mice. Nat Immunol. 2008 Feb;9(2):166-75
J:143719 Ishigame H, et al., Differential roles of interleukin-17A and -17F in host defense against mucoepithelial bacterial infection and allergic responses. Immunity. 2009 Jan;30(1):108-19
J:145142 Shibata K, et al., Resident Vdelta1+ gammadelta T cells control early infiltration of neutrophils after Escherichia coli infection via IL-17 production. J Immunol. 2007 Apr 1;178(7):4466-72
J:153022 Kuestner RE, et al., Identification of the IL-17 receptor related molecule IL-17RC as the receptor for IL-17F. J Immunol. 2007 Oct 15;179(8):5462-73
J:155093 Liang SC, et al., An IL-17F/A heterodimer protein is produced by mouse Th17 cells and induces airway neutrophil recruitment. J Immunol. 2007 Dec 1;179(11):7791-9
J:161481 Cho JS, et al., IL-17 is essential for host defense against cutaneous Staphylococcus aureus infection in mice. J Clin Invest. 2010 May 3;120(5):1762-73
J:191712 Gladiator A, et al., Cutting Edge: IL-17-Secreting Innate Lymphoid Cells Are Essential for Host Defense against Fungal Infection. J Immunol. 2013 Jan 15;190(2):521-5
J:233769 Lee JS, et al., Interleukin-23-Independent IL-17 Production Regulates Intestinal Epithelial Permeability. Immunity. 2015 Oct 20;43(4):727-38
J:246922 Wang X, et al., IL-17A Promotes Pulmonary B-1a Cell Differentiation via Induction of Blimp-1 Expression during Influenza Virus Infection. PLoS Pathog. 2016 Jan;12(1):e1005367
J:254537 St Leger AJ, et al., An Ocular Commensal Protects against Corneal Infection by Driving an Interleukin-17 Response from Mucosal gammadelta T Cells. Immunity. 2017 Jul 18;47(1):148-158.e5
J:264984 Acharya D, et al., Interleukin-17A Promotes CD8+ T Cell Cytotoxicity To Facilitate West Nile Virus Clearance. J Virol. 2017 Jan 1;91(1)
J:266885 Chen K, et al., IL-17 Receptor Signaling in the Lung Epithelium Is Required for Mucosal Chemokine Gradients and Pulmonary Host Defense against K. pneumoniae. Cell Host Microbe. 2016 Nov 9;20(5):596-605