Sequence Detail

ID/Version

Q63ZV0 Q9Z113 (UniProt | EBI)

Last sequence update: 2004-10-25
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Insulinoma-associated protein 1;AltName: Full=Zinc finger protein IA-1;

Provider

SWISS-PROT

Sequence

Polypeptide 521 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Insm1	insulinoma-associated 1	55	124	3	11

Sequence references in MGI

J:77887 Xie J, et al., The Zinc-Finger Transcription Factor INSM1 Is Expressed during Embryo Development and Interacts with the Cbl-Associated Protein. Genomics. 2002 Jul;80(1):54-61
J:85721 Breslin MB, et al., NeuroD1/E47 regulates the E-box element of a novel zinc finger transcription factor, IA-1, in developing nervous system. J Biol Chem. 2003 Oct 3;278(40):38991-7
J:106988 Mellitzer G, et al., IA1 is NGN3-dependent and essential for differentiation of the endocrine pancreas. EMBO J. 2006 Mar 22;25(6):1344-52
J:112173 Gierl MS, et al., The Zinc-finger factor Insm1 (IA-1) is essential for the development of pancreatic beta cells and intestinal endocrine cells. Genes Dev. 2006 Sep 1;20(17):2465-78
J:130853 Wildner H, et al., Insm1 (IA-1) is a crucial component of the transcriptional network that controls differentiation of the sympatho-adrenal lineage. Development. 2008 Feb;135(3):473-81
J:144651 Farkas LM, et al., Insulinoma-associated 1 has a panneurogenic role and promotes the generation and expansion of basal progenitors in the developing mouse neocortex. Neuron. 2008 Oct 9;60(1):40-55
J:206319 Welcker JE, et al., Insm1 controls development of pituitary endocrine cells and requires a SNAG domain for function and for recruitment of histone-modifying factors. Development. 2013 Dec;140(24):4947-58