ID/Version |
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Sequence description from provider |
RecName: Full=Helix-loop-helix protein 2; Short=HEN-2;AltName: Full=Nescient helix loop helix 2; Short=NSCL-2; | ||||||||||||||
Provider | SWISS-PROT | ||||||||||||||
Sequence |
Polypeptide
135
aa
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Source | |||||||||||||||
Annotated genes and markers |
Follow the symbol links to get more information on the GO terms,
expression assays, orthologs, phenotypic alleles, and other information
for the genes or markers below.
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Sequence references in MGI |
J:20956
Gobel V, et al., NSCL-2: a basic domain helix-loop-helix gene expressed in early neurogenesis. Cell Growth Differ. 1992 Mar;3(3):143-8
J:31447 Haire MF, et al., Transient expression of the basic helix-loop-helix protein NSCL-2 in the mouse cerebellum during postnatal development. Brain Res Mol Brain Res. 1996 Feb;36(1):174-8 J:39356 Good DJ, et al., Hypogonadism and obesity in mice with a targeted deletion of the Nhlh2 gene. Nat Genet. 1997 Apr;15(4):397-401 J:93303 Kruger M, et al., NSCL-1 and NSCL-2 synergistically determine the fate of GnRH-1 neurons and control necdin gene expression. EMBO J. 2004 Nov 27;23(21):4353-64 J:96351 Coyle CA, et al., Reduced voluntary activity precedes adult-onset obesity in Nhlh2 knockout mice. Physiol Behav. 2002 Nov;77(2-3):387-402 J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563 J:101925 Johnson SA, et al., The Nhlh2 transcription factor is required for female sexual behavior and reproductive longevity. Horm Behav. 2004 Nov;46(4):420-7 J:125013 Schmid T, et al., NSCL-1 and -2 control the formation of precerebellar nuclei by orchestrating the migration of neuronal precursor cells. J Neurochem. 2007 Sep;102(6):2061-72 J:127370 Cogliati T, et al., Pubertal Impairment in Nhlh2 Null Mice Is Associated with Hypothalamic and Pituitary Deficiencies. Mol Endocrinol. 2007 Dec;21(12):3013-3027 J:136071 Fox DL, et al., Nescient helix-loop-helix 2 interacts with signal transducer and activator of transcription 3 to regulate transcription of prohormone convertase 1/3. Mol Endocrinol. 2008 Jun;22(6):1438-48 J:148882 Ruschke K, et al., Defective peripheral nerve development is linked to abnormal architecture and metabolic activity of adipose tissue in Nscl-2 mutant mice. PLoS One. 2009;4(5):e5516 J:164012 Wankhade UD, et al., Deletion of Nhlh2 results in a defective torpor response and reduced Beta adrenergic receptor expression in adipose tissue. PLoS One. 2010;5(8) J:183737 Wankhade UD, et al., Melanocortin 4 receptor is a transcriptional target of nescient helix-loop-helix-2. Mol Cell Endocrinol. 2011 Jul 20;341(1-2):39-47 J:199640 Schmid T, et al., Loss of NSCL-2 in gonadotropin releasing hormone neurons leads to reduction of pro-opiomelanocortin neurons in specific hypothalamic nuclei and causes visceral obesity. J Neurosci. 2013 Jun 19;33(25):10459-70 |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 08/02/2024 MGI 6.24 |
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