Sequence Detail

ID/Version

Q64221 Q8BFV7 (UniProt | EBI)

Last sequence update: 2012-10-03
Last annotation update: 2024-05-29

Sequence description from provider

RecName: Full=Helix-loop-helix protein 2; Short=HEN-2;AltName: Full=Nescient helix loop helix 2; Short=NSCL-2;

Provider

SWISS-PROT

Sequence

Polypeptide 135 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Nhlh2	nescient helix loop helix 2	21	121	3	11

Sequence references in MGI

J:20956 Gobel V, et al., NSCL-2: a basic domain helix-loop-helix gene expressed in early neurogenesis. Cell Growth Differ. 1992 Mar;3(3):143-8
J:31447 Haire MF, et al., Transient expression of the basic helix-loop-helix protein NSCL-2 in the mouse cerebellum during postnatal development. Brain Res Mol Brain Res. 1996 Feb;36(1):174-8
J:39356 Good DJ, et al., Hypogonadism and obesity in mice with a targeted deletion of the Nhlh2 gene. Nat Genet. 1997 Apr;15(4):397-401
J:93303 Kruger M, et al., NSCL-1 and NSCL-2 synergistically determine the fate of GnRH-1 neurons and control necdin gene expression. EMBO J. 2004 Nov 27;23(21):4353-64
J:96351 Coyle CA, et al., Reduced voluntary activity precedes adult-onset obesity in Nhlh2 knockout mice. Physiol Behav. 2002 Nov;77(2-3):387-402
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:101925 Johnson SA, et al., The Nhlh2 transcription factor is required for female sexual behavior and reproductive longevity. Horm Behav. 2004 Nov;46(4):420-7
J:125013 Schmid T, et al., NSCL-1 and -2 control the formation of precerebellar nuclei by orchestrating the migration of neuronal precursor cells. J Neurochem. 2007 Sep;102(6):2061-72
J:127370 Cogliati T, et al., Pubertal Impairment in Nhlh2 Null Mice Is Associated with Hypothalamic and Pituitary Deficiencies. Mol Endocrinol. 2007 Dec;21(12):3013-3027
J:136071 Fox DL, et al., Nescient helix-loop-helix 2 interacts with signal transducer and activator of transcription 3 to regulate transcription of prohormone convertase 1/3. Mol Endocrinol. 2008 Jun;22(6):1438-48
J:148882 Ruschke K, et al., Defective peripheral nerve development is linked to abnormal architecture and metabolic activity of adipose tissue in Nscl-2 mutant mice. PLoS One. 2009;4(5):e5516
J:164012 Wankhade UD, et al., Deletion of Nhlh2 results in a defective torpor response and reduced Beta adrenergic receptor expression in adipose tissue. PLoS One. 2010;5(8)
J:183737 Wankhade UD, et al., Melanocortin 4 receptor is a transcriptional target of nescient helix-loop-helix-2. Mol Cell Endocrinol. 2011 Jul 20;341(1-2):39-47
J:199640 Schmid T, et al., Loss of NSCL-2 in gonadotropin releasing hormone neurons leads to reduction of pro-opiomelanocortin neurons in specific hypothalamic nuclei and causes visceral obesity. J Neurosci. 2013 Jun 19;33(25):10459-70