Sequence Detail

ID/Version

Q64279 Q61099 (UniProt | EBI)

Last sequence update: 1996-11-01
Last annotation update: 2024-11-27

Sequence description from provider

RecName: Full=Heart- and neural crest derivatives-expressed protein 1;AltName: Full=Extraembryonic tissues, heart, autonomic nervous system and neural crest derivatives-expressed protein 1; Short=eHAND;AltName: Full=Helix-loop-helix transcription

Provider

SWISS-PROT

Sequence

Polypeptide 216 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Hand1	heart and neural crest derivatives expressed 1	79	205	2	17

Sequence references in MGI

J:26206 Hollenberg SM, et al., Identification of a new family of tissue-specific basic helix-loop-helix proteins with a two-hybrid system. Mol Cell Biol. 1995 Jul;15(7):3813-22
J:28009 Cross JC, et al., Hxt encodes a basic helix-loop-helix transcription factor that regulates trophoblast cell development. Development. 1995 Aug;121(8):2513-23
J:28312 Cserjesi P, et al., Expression of the novel basic helix-loop-helix gene eHAND in neural crest derivatives and extraembryonic membranes during mouse development. Dev Biol. 1995 Aug;170(2):664-78
J:46383 Riley P, et al., The Hand1 bHLH transcription factor is essential for placentation and cardiac morphogenesis. Nat Genet. 1998 Mar;18(3):271-5
J:109087 Yamada K, et al., Sox15 enhances trophoblast giant cell differentiation induced by Hand1 in mouse placenta. Differentiation. 2006 Jun;74(5):212-21
J:113904 Firulli BA, et al., The basic helix-loop-helix transcription factors dHAND and eHAND exhibit dimerization characteristics that suggest complex regulation of function. J Biol Chem. 2000 Oct 27;275(43):33567-73
J:152657 Martindill DM, et al., Nucleolar release of Hand1 acts as a molecular switch to determine cell fate. Nat Cell Biol. 2007 Oct;9(10):1131-41